The Brand Name FRAULINE Has Generic Salt :: CYPROTERONE 

FRAULINE  Is From Company NPIL Priced :: Rs. 195

FRAULINE have CYPROTERONE is comes under Sub class #N/A of  Main Class #N/A

Main Medicine Class:: #N/A  Sub Medicine Class :: #N/A 

 Salt Name :  OR Generic Name Form Price : MRP /Probable Packing
CYPROTERONE  TAB  Rs. 195  28
Brand Name Company / Manufacturers Strength Unit Price / 28
 FRAULINE  NPIL  2,0.035;MG  28 Rs. 195

Company  Brand Name  Salt Combination Main Medical Class Sub Medical Class
 From NPIL :: FRAULINE  CYPROTERONE  #N/A #N/A

Indications for Drugs ::

Acne, Contraception, Hirsutism, Prostatic carcinoma, Libido, Hot flushes

Drug Dose ::

Adult: PO Acne; Contraception; Hirsutism 2 mg/day (w/ ethinylestradiol) for 21 days of the menstrual cycle. Palliative treatment for prostatic carcinoma Initial: 300 mg/day in 2-3 divided doses. Maintenance: 200-300 mg/day. Control of libido 50 mg twice daily. Hot flushes 50mg/day, may increase to 150 mg/day in 3 divided doses if needed.

Contraindication ::

Markedly impaired liver function or cholestasis; Dubin-Johnson or Rotor syndrome, hepatic adenoma; malignant or wasting diseases; severe chronic depression; severe diabetes with vascular changes; sickle-cell anaemia; history of thromboembolic disorders; renal impairment. Youths <18 yr. Drug Precautions ::

Prostate cancer, hepatic impairment, DM, history of depression, familial defects in lipoprotein metabolism, CV diseases. Monitor LFT, adrenocortical function, LDL and HDL levels, and RBC count during treatment. In women: Interrupt treatment if persistent or recurrent bleeding occurs to exclude the possibility of organic diseases. May increase risk of thrombo-embolic diseases. Ineffective for male hypersexuality in chronic alcoholism. May impair ability to drive or operate machinery. Pregnancy, lactation.

Drug Side Effects ::

Inhibits spermatogenesis, reduces volume of ejaculate, causes infertility, produces abnormal spermatozoa, gynecomastia and enlargement of mammary glands; galactorrhoea and benign nodules. Depressive mood changes. Alterations in hair pattern, skin reactions. Fatigue and lassitude, breathlessness, wt changes.

Pregnancy category ::
Pregnancy category

5

Drug Mode of Action ::  

Cyproterone is a progestogen with anti-androgenic properties.Oestradiol is the major oestrogen in pre-menopausal women. Ethinylestradiol has similar actions as oestradiol. It is responsible for the development and maintenance of female reproductive system and secondary sexual characteristics. It also inhibits anterior pituitary by negative feedback effect and causes capillary dilation, fluid retention and protein anabolism.

Drug Interactions ::

Metabolism may be reduced by inhibitors of CYP3A4 e.g. ketoconazole, itraconazole, clotrimazole, ritonavir. Inducers of CYP3A4 e.g. rifampicin, phenytoin may reduce the levels of cyproterone. CYP1A2 and CYP3A4 inducers such as aminoglutethimide, carbamazepine, phenobarbital, and rifampin may decrease the effects of estradiol. May enhance the effects of hydrocortisone and prednisolone when used together. Altered anticoagulant effect when used with dicoumarol. Potentially Fatal: Antibiotics (ampicillin, tetracycline, sulphonamides and chloramphenicol) can cause intermenstrual bleeding or failure of contraception. Reduced efficacy of antihypertensives or hypoglycaemic drugs.

 

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