The Brand Name FRUSENEX Has Generic Salt :: Frusemide 

FRUSENEX  Is From Company Geno Ph. Priced :: Rs. 17.66

FRUSENEX have Frusemide is comes under Sub class #N/A of  Main Class #N/A

Main Medicine Class:: #N/A  Sub Medicine Class :: #N/A 

Indications for Drugs ::

Hypertension, Congestive heart failure, Nephrotic syndrome, Hypercalcemia, Edema, Cirrhosis, Renal impairment, Cerebral/pulmonary edema, Pulmonary oedema, Acute renal failure, Chronic renal failure

Drug Dose ::

Adult: PO HTN 40-80 mg/day. Oedema Initial: 20 mg/day. Max: 600 mg/day in severe cases. IV Pulmonary oedema 40 mg, if response is inadequate w/in 1 hr, a further dose of 80 mg may be given. Oliguria in acute or chronic renal failure For GFR: 5-20 mL/min: Infuse 250 mg over 1 hr. If urine output is insufficient w/in the next hr, may follow by 500 mg infused over 2 hr. If urine output is still unsatisfactory w/in 1 hr after the 2nd infusion, a 3rd dose of 1 g may be infused over 4 hr. Rate of infusion: <4 mg/min. If the response is satisfactory, may repeat the effective dose (of up to 1 g) every 24 hr. IM/IV Oedema 20-50 mg, may increase in steps of 20 mg 2 hrly if needed. Doses >50 mg must be given as IV infusion.

Contraindication ::

Severe sodium and water depletion, hypersensitivity to sulphonamides and furosemide, hypokalaemia, hyponatraemia, precomatose states associated with liver cirrhosis, anuria or renal failure. Addison’s disease.

Drug Precautions ::

Prostatic hyperplasia. Hepatic or renal impairment, gout, DM, impaired micturition. Infusion rate should not exceed 4 mg/min to reduce the risk of ototoxicity. Monitor fluid and electrolyte balance and renal function. May lower serum levels of calcium and magnesium, thus serum levels should be monitored. Pregnancy and lactation.

Drug Side Effects ::

Fluid and electrolyte imbalance. Rashes, photosensitivity, nausea, diarrhoea, blurred vision, dizziness, headache, hypotension. Bone marrow depression (rare), hepatic dysfunction. Hyperglycaemia, glycosuria, ototoxicity. Potentially Fatal: Rarely, sudden death and cardiac arrest. Hypokalaemia and magnesium depletion can cause cardiac arrhythmias.

Pregnancy category ::

3

Drug Mode of Action ::  

Furosemide inhibits reabsorption of Na and chloride mainly in the medullary portion of the ascending Loop of Henle. Excretion of potassium and ammonia is also increased while uric acid excretion is reduced. It increases plasma-renin levels and secondary hyperaldosteronism may result. Furosemide reduces BP in hypertensives as well as in normotensives. It also reduces pulmonary oedema before diuresis has set in.

Drug Interactions ::

Analgesics reduce natriuretic action of furosemide. Antagonises hypoglycaemic agents and drugs used for gout. Hyperglycaemia with antihypertensive agent diazoxide. Antagonises muscle relaxants. Increased risk of ototoxicity when used with aminoglycosides especially in renal impairment. May enhance nephrotoxicity of cephalosporins. Effects of antihypertensives enhanced. Action antagonised by corticosteroids. Phenytoin and indometacin may reduce effects of furosemide. Potentially Fatal: May provoke severe hypotensive response with ACE inhibitors. NSAIDs inhibit diuretic and antihypertensive effects. Increased incidence of premature beats with cardiac glycosides.