Indications & Dose: DIABETIC NEUROPATHY PO Adult 900-3600mg/day | EPILEPSY PO Adult 300mg on day 1, 300mg BID day 2, 300mg TID day 3, then increase by 300mg q2-3days until control is achieved, max 4.8g/day (total daily dose should be taken in 3 equally divided doses & max dosage interval should not exceed 12h) | FOCAL SEIZURES WITH OR WITHOUT SECONDARY GENERALISATION Mono therapy PO Child 12–18 yr: Initially 300mg TID day 1 then increase by 300mg in 3 divided doses q2–3days, usual dose 0.9–3.6g/day in 3 divided doses | Adjunct therapy PO Child 2–6 yr: 10mg/kg OD day 1, 10mg/kg BID day 2, 10mg/kg TID day 3, increased to 30-70mg/kg/day in 3 divided doses based on response, 6–12 yr: 10mg/kg max 300mg OD day 1, 10mg/kg (max 300mg) BID day 2, 10mg/kg max 300mg TID day 3; usual dose 25–35mg/kg daily in 3 divided doses, max 70mg/kg/day 3 divided doses, 12–18 yr: Initially 300mg TID day 1 then increase by 300mg in 3 divided doses q2–3days, usual dose 0.9–3.6g/day in 3 divided doses | POSTHERPETIC NEURALGIA/NEUROPATHIC PAIN PO Adult Day1: 300mg/day, Day2: 300mg BID, Day3: 300mg TID, max 3.6g/day | RESTLESS LEGS SYNDROME PO Adult Initially 300mg/day HS, doses >600mg/day given in 2 divided doses

Precautions: Avoid abrupt withdrawal, elderly, renal impairment, DM

ADR: Serious: SJS, pancreatitis, hepatitis, jaundice, thrombocytopenia, ARF, Others: Diarrhea, dyspepsia, nausea, vomiting, abdominal pain, constipation, flatulence, gingivitis, HTN, edema, confusion, dizziness, headache, anxiety, ataxia, nystagmus, tremor, paraesthesia, urinary incontinence, impotence, leucopenia, myalgia, arthralgia, diplopia, pruritus, acne, hallucinations, alopecia, tinnitus

DDI: Serious Irinotecan clearance is increased, Morphine increases drug bioavailability, Phenytoin/Antacids level is increased

Diet: With/without food

Monitor: Serum drug level, suicidality