Article Contents ::
Details About Generic Salt :: Galantamine
Main Medicine Class:: #N/A Sub Medicine Class :: #N/A
| 1F. DRUGS FOR NEURODEGENERATIVE DISORDERS in 1. NERVOUS SYSTEM |
| GALANTAMINE |
| CHOLINESTERASE INHIBITOR | ANTI-ALZHEIMER |
| PK: A: Rapid & complete D: 175 L M: Hepatic E: Urine |
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Indications & Dose: ALZHEIMER’S DISEASE PO Adult Initially 4mg BID 4 wk, then increase to 8mg BID 4 wk, may be increase to 12mg BID according to response and tolerance |
| Contra: Hypersensitivity, severe renal/hepatic dysfunction
Precautions: Respiratory disease, PUD, cardiac conduction abnormalities, seizures, urinary tract obstruction, mild-to-moderate hepatic impairment, moderate renal impairment ADR: Serious: Bradycardia, syncope, tremor, rhinitis, Others: anemia, nausea, vomiting, anorexia, diarrhea, weight loss, abdominal pain, dyspepsia, flatulence, hematuria, dizziness, headache, depression, insomnia DDI: Serious Atropine causes antagonistic effects, Ketoconazole/Fluoxetine/Paroxetine/Quinidine increases drug level, β-blockers increases risk of bradycardia, Diltiazem/Amiodarone/Verapamil leads to bradycardia Diet: With food Monitor: Mental status |