Article Contents ::
Details About Generic Salt :: Gefitinib
Main Medicine Class:: Anti Neoplastic Agents Sub Medicine Class :: Anti Neoplastic Agents
| 18A. ANTI-NEOPLASTIC AGENTS in 18. ANTI-NEOPLASTIC AGENTS |
| GEFITINIB |
| EPIDERMAL GROWTH FACTOR RECEPTOR INHIBITOR | ANTI-NEOPLASTIC |
| PK: A: Slow (PO) D: 1400 L M: Hepatic E: Feces (86%), urine (<4%) |
|
Indications & Dose: NON-SMALL CELL LUNG CANCER PO Adult 250mg/day |
| Contra: Hypersensitivity
Precautions: Hepatic impairment/hepatotoxicity, idiopathic pulmonary fibrosis, concurrent use of CYP3A4 inducers ADR: Serious: CNS hemorrhage, peripheral edema, conjunctivitis, hematuria, ocular hemorrhage, TEN, angioedema, interstitial lung disease, interstitial pneumonia, Others: epistaxis, erythema multiforme, urticaria, corneal erosion/ulcer, rash, diarrhea, nausea, vomiting, pruritus, anorexia, weight loss, mouth ulceration, weakness, amblyopia, acne, dry skin, paronychia, dyspnea DDI: Serious Carbamazepine/Barbiturates/Phenytoin decreases drug levels & its efficacy, Warfarin effects increases, Itraconazole/HIV protease inhibitors/Ketoconazole/Macrolides/Voriconazole raises drug levels & might increases its efficacy Diet: With/without food Monitor: LFTs, INR/PT, pulmonary symptoms |
