The Brand Name GOLBI Has Generic Salt :: Ursodeoxycholic 

GOLBI  Is From Company Intas Priced :: Rs. 207

GOLBI have Ursodeoxycholic is comes under Sub class Hepatoprotectives, Cholelitholytics,Gall Stone Solubilizers of  Main Class Hepatobiliary System

Main Medicine Class:: Hepatobiliary System  Sub Medicine Class :: Hepatoprotectives, Cholelitholytics,Gall Stone Solubilizers 

Indications for Drugs ::

Dissolution of cholesterol-rich gallstones, Primary biliary cirrhosis, Prevention of gallstones

Drug Dose ::

Adult: PO Dissolution of cholesterol-rich gallstones 6-12 mg/kg/day as a single dose at bedtime after radiological disappearance of stones. Max: 15 mg/kg. Primary biliary cirrhosis 10-15 mg/kg/day in 2-4 divided doses. Prevention of gallstones in patients undergoing rapid wt loss 300 mg twice daily.

Contraindication ::

Calcified and pigment gallstones, radio opaque gallstones. Nonfunctioning gall bladders; chronic liver and peptic ulcer disease. Inflammatory disease of colon and small intestine. Pregnancy.

Drug Precautions ::

50% of successfully treated patients will develop further gallstones within 10 yr. Lactation.

Drug Side Effects ::

Diarrhoea, pruritus, nausea, vomiting, gallstone calcification.

Pregnancy category ::

2

Drug Mode of Action ::  

Ursodeoxycholic acid suppresses hepatic synthesis and secretion of cholesterol and also inhibits intestinal absorption of cholesterol.

Drug Interactions ::

Cholestyramine, charcoal and antacids may reduce effectiveness. Aluminum-based antacids may reduce absorption. Oestrogens and clofibrate may counteract effectiveness of ursodeoxycholic acid by increasing cholesterol elimination in bile. Possible increase in ciclosporin serum concentration. Decreased effectiveness of dapsone. Possible decrease in serum ciprofloxacin and nitrendipine.