Indications & Dose: ANXIETY DISORDERS PO Adult 500µg BID | CONFUSION PO Adult 1-3mg TID | NAUSEA PO Adult 1mg/day | Palliative therapy PO Adult 1.5mg OD/BID increased to 5-10mg/day in divided doses Child 12-18 yrs: 1.5mg OD HS increased to 1.5mg BID if needed, max 5mg BID | Palliative therapy IV/SC Adult Inf: 2.5-10mg over 24h hours Child 1 month-12 yrs: 25-85 µg/kg over 24h, 12-18 yrs: 1.5-5mg over 24h | IM Adult 0.5-2mg | PSYCHOSIS PO Adult 0.5-5mg BID/TID, max 30mg/day MD 3-10mg/day Child 3-12 yr (15-40 kg): Initially 0.25-0.5mg/kg/day in 2-3 divided doses increase by 0.25-0.5mg q5-7 days, max 0.15mg/kg/day MD 0.05-0.15mg/kg/day in 2-3 divided doses, 12-18 yr: Initially 0.5-3 mg BID/TID | IM Adult 2-5mg q4-8h as needed (as lactate) or 10-20 times the daily oral dose at 4-wk intervals (as decanaote) MD 10-15 times initial oral dose | RESTLESSNESS PO Adult 1-3mg TID | RESTLESSNESS/CONFUSION SC Adult 5-15mg over 24h given as inf | SEVERE TICS PO Child 5-12 yrs: 12.5-25 µg/kg BID up to 10mg/day, 12-18 yrs: 1.5mg TID, up to 10mg/day | TOURETTE’S SYNDROME PO Child 5-12 yr: 12.5-25µg/kg BID up to 10mg/day, 12-18 yr: 1.5mg TID, up to 10mg/day | VOMITING PO Adult 1mg/day | Palliative therapy PO Adult 1.5mg OD/BID increased to 5-10mg/day in divided doses Child 12-18 yrs: 1.5mg OD HS increased to 1.5mg BID if needed, max 5mg BID | Palliative therapy IV/SC Adult Inf: 2.5-10mg over 24h hours Child 1 month-12 yrs: 25-85 µg/kg over 24h, 12-18 yrs: 1.5-5mg over 24h | IM Adult 0.5-2mg

Precautions: CVD, dementia, glaucoma, myasthenia gravis, renal impairment, thyroid dysfunction, parkinson’s disease

ADR: Serious: Seizures, NMS, torsades de pointes (with IV use), pseudoparkinsonian signs & symptoms, hyper/hypoglycemia, significant EPS, jaundice, blurred vision, bronchospasm, heat stroke, Others: urinary retention, headache, insomnia, lethargy, lactation, anorexia, constipation, sexual dysfunction, diarrhea, dyspepsia, hypersalivation, nausea, vomiting, xerostomia, restlessness, vertigo, alopecia, contact dermatitis, hyperpigmentation, rash, amenorrhea, galactorrhea, gynecomastia, confusion, depression, drowsiness, dystonic reactions, euphoria

DDI: Serious Dexamphetamine causes acute dystonia, Imipenem causes marked but transient hypotension, Amiodarone causes QT prolongation, Amphetamine central stimulant effects inhibited, Phenytoin/Phenobarbital decreases plasma levels of drug, Ritonavir/Chlorpromazine/Venlafaxine increases drug levels, Azoles increases plasma levels of drug, Antidiabetics increases risk of needing insulin, Sotalol increases risk of QT prolongation, Alcohol induces extrapyramidal reactions, Fluoxetine leads to extrapyramidal adverse effects, Methyl dopa leads to marked CNS adverse effects, Carbamazepine levels increases & causes neurotoxicity & SJS, Quinidine markedly increases drug levels, Rifampicin reduces serum levels of drug, Topiramate slightly increases drug levels, Lithium worsens EPS

Diet:

Monitor: Vital signs, Lipid profile, FBS, BMI, EPS, ECG