The Brand Name IFEX-M Has Generic Salt :: Ifosfamide 

IFEX-M  Is From Company Biochem Priced :: Rs. 396

IFEX-M have Ifosfamide is comes under Sub class Anti Neoplastic Agents of  Main Class Anti Neoplastic Agents

Main Medicine Class:: Anti Neoplastic Agents  Sub Medicine Class :: Anti Neoplastic Agents 

Indications for Drugs ::

Breast cancer, Lung cancer, Ovarian cancer, Lymphoma, Testicular cancer, Soft tissue sarcoma, Osteogenic sarcoma, Cervical cancer

Drug Dose ::

Adult: IV Lymphoma; Sarcoma; Solid tumours Different licensed dosage regimens are available. 8-12 g/m2 divided over 3-5 days, repeat course 2-4 wkly. Germ cell testicular carcinoma W/ mesna and adequate hydration: 1.2 g/m2/day for 5 days, repeat treatment 3 wkly or after recovery from haematological toxicity. Renal impairment: CrCl (ml/min) <10 Administer 75% of dose. Contraindication ::

Hypersensitivity; severe bone-marrow depression. Pregnancy, lactation.

Drug Precautions ::

Hepatic or renal dysfunction, compromised bone marrow reserve. Use with mesna and ensure high oral/IV fluid intake to reduce urotoxic effects.

Drug Side Effects ::

Confusion, alopoecia, nausea, vomiting, phloebitis, somnolence, depression, hallucinations. Wound healing may be impaired during ifosfamide use. Potentially Fatal: Severe myelosuppression, haemorrhagic cystitis, nephrotoxicity, cardiotoxicity, coma.

Pregnancy category ::

4

Drug Mode of Action ::  

Ifosfamide is converted to its active metabolites via hepatic microsomal enzymes. These active metabolites act as alkylating agents, disrupting DNA and protein synthesis of the target cells. It is routinely given with mesna to reduce urothelial toxicity.

Drug Interactions ::

Causes enhanced toxicity with allopurinol, cisplatin. Ifosfamide enhances the anticoagulant effect of warfarin. CYP2A6 inducers (e.g. amobarbital, pentobarbital, phenobarbital, rifampin and secobarbital) may reduce serum levels of ifosfamide while the inhibitors (e.g. isoniazid, methoxsalen and miconazole) may increase its serum levels. CYP3A4 inducers (e.g. aminoglutethimide, carbamazepine, nafcillin, nevirapine, phenobarbital, phenytoin, and rifamycins) may reduce serum levels of ifosfamide while the inhibitors (e.g. azole antifungals, clarithromycin, diclofenac, doxycycline, erythromycin, imatinib, isoniazid) may increase its serum levels.