Indications & Dose: DENTAL PAIN Mild-to-moderate PO Adult 25-50mg q6-8h max 300mg/day Child >16 yr: Same as adult dose | DYSMENORRHEA Mild-to-moderate PO Adult 25-50mg q6-8h, max 300mg/day | EXACERBATIONS OF MUSCULOSKELETAL DISORDERS Acute IM Adult 50-100mg deep into the gluteal muscle q4h max 200mg/day 3 days | JOINT DISORDERS IM Adult 50-100mg deep into the gluteal muscle q4h max 200mg/day 3 days | OSTEOARTHRITIS PO Adult 50mg QID or 75mg TID max 300mg/day, ER: 200mg OD Elderly Use lower dose | PAIN AFTER ORTHOPAEDIC SURGERY IM Adult 50-100mg deep into the gluteal muscle q4h, max 200mg/day 3 days | PERI-ARTICULAR & SOFT-TISSUE DISORDERS IM Adult 50-100mg deep into the gluteal muscle q4h max 200mg/day 3 days | RHEUMATIC DISEASE RECTAL Adult Suppositories: 100mg HS, max total daily dose 200mg/day (including oral & rectal treatment) | RHEUMATOID ARTHRITIS PO Adult 50mg QID or 75mg TID max 300mg/day, ER: 200mg OD Elderly Use lower dose

Precautions: Asthma, HTN, renal/hepatic impairment, elderly, fluid retention, patients with infect, history of GI diseases

ADR: Serious: Severe GI bleeding, blood disorders, nephrotoxicity, hematuria, nephropathy, angioedema, bronchospasm, aseptic meningitis, pancreatitis, tinnitus, peripheral edema, renal dysfunction, fluid retention, Others: headache, abdominal pain, dizziness, nervousness, depression, constipation, stomatitis, vomiting, visual disturbances, UTI, insomnia, flatulence, diarrhea, somnolence, rash, anorexia, nausea

DDI: Serious Neostigmine leads to aggravation of myasthenic symptoms, Lithium/Cyclosporine levels increased, Aluminium hydroxide reduces drug absorption, Probenecid reduces drug clearance

Diet: With food

Monitor: CBC, chemistry profile, occult blood loss, LFTs, renal function test