Article Contents ::
Details About Generic Salt :: Lacosamide
Main Medicine Class:: Nervous System Sub Medicine Class :: Drugs for Neuropathic Pain
| 1J. DRUGS FOR NEUROPATHIC PAIN in 1. NERVOUS SYSTEM |
| LACOSAMIDE |
| FUNCTIONALIZED AMINO ACID | ANTI-EPILEPTIC |
| also comes under 1C. Anti-Epileptics in 1. Nervous System, |
| PK: A: Complete D: 0.6L/kg (Vd) M: Hepatic E: Urine, feces |
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Indications & Dose: NEUROPATHIC PAIN PO Adult 50mg BID, increase subsequent wk to 200-300mg BID | PARTIAL SEIZURES PO/IV Adult 50mg TID, increase 100mg/day in 2 divided doses at weekly intervals, MD 200-400mg/day |
| Contra: Hypersensitivity, second/third degree AV block, severe hepatic impairment
Precautions: Conduction problems, severe CVD, elderly, hepatic/renal impairment, during withdrawal ADR: Serious: atrial fibrillation & atrial flutter, syncope, hypersensitivity, Suicidal behavior, diplopia, nystagmus, tremor, PR-interval prolongation, Others: fatigue, pruritus, impaired coordination, ataxia, nausea, vomiting, flatulence, constipation, dizziness, headache, depression DDI: Serious Anti-Arrhythmics enhances PR prolongation, Rifampicin reduces drug level Diet: With/without food Monitor: ECG, suicidality |
