Indications & Dose: MULTIPLE MYELOMA Combination therapy PO Adult 25mg/day given for 21 days of a 28 day treatment cycle. Give along with dexamethasone [40mg/day on 1-4, 9-12 & 17-20 days of first 4 cycles & repeat only 1-4 days of each cycle thereafter] | MYELODYSPLASTIC SYNDROME WITH 5Q DELETION PO Adult 10mg/day

Precautions: renal impairment

ADR: Serious: hypotension, tremor, hypoaesthesia, peripheral neuropathy, cardiac disorders, hepatotoxicity, hypothyroidism, hypomagnesemia, hypocalcemia, sinusitis, rhinitis, bronchitis, hypoxia, Anemia, neutropenia, thrombocytopeni, DVT, PE, muscle cramp, Others: GI disturbances, pruritus, rash, fatigue, fatigue, insomnia

DDI: Others Digoxin levels slightly increase

Monitor: CBC, SeCr, LFT, thyroid function test, ECG, for thromboembolism