The Brand Name LOMUSTINE Has Generic Salt :: Lomustine 

LOMUSTINE  Is From Company GSK Priced :: Rs. 660

LOMUSTINE have Lomustine is comes under Sub class Anti Neoplastic Agents of  Main Class Anti Neoplastic Agents

Main Medicine Class:: Anti Neoplastic Agents  Sub Medicine Class :: Anti Neoplastic Agents 

Indications for Drugs ::

Brain tumours; Hodgkin’s disease; Lung cancer; Malignant melanoma

Drug Dose ::

Oral Brain tumours, Hodgkin’s disease, resistant or relapsed, Malignant melanoma, Lung cancer Adult: 100-130 mg/m2 as a single dose every 6 wk. Adjust dose according to platelet and leukocyte counts. Compromised marrow function: 100 mg/m2 as a single dose every 6 wk. Child: 75-150 mg/m2 as a single dose every 6 wk. Readjust dose according to platelet and leukocyte counts. Renal impairment: CrCl (ml/min) 10-50 Admin 75% of normal dose. <10 Admin 25-50% of normal dose. Contraindication ::

Pregnancy and lactation.

Drug Precautions ::

Monitor CBC with differential platelet count wkly for at least 6 wk after a dose. Periodically perform pulmonary function studies and LFTs.

Drug Side Effects ::

Pulmonary infiltrates, pulmonary fibrosis, nausea, vomiting, hepatotoxicity, nephrotoxicity, stomatitis, alopecia, disorientation, lethargy, dysarthria, ataxia, visual disturbances. Potentially Fatal: Delayed bone marrow suppression and permanent marrow damage following prolonged use.

Pregnancy category ::

4

Drug Mode of Action ::  

Lomustine inhibits the synthesis of DNA and RNA via alkylation although carbamoylation and modification of cellular proteins may also be involved.

Drug Interactions ::

Increased levels/effects with CYP2D6 inhibitors.