The Brand Name NEX Has Generic Salt :: Naloxone 

NEX  Is From Company Neon Priced :: Rs. 85.5

NEX have Naloxone is comes under Sub class #N/A of  Main Class #N/A

Main Medicine Class:: #N/A  Sub Medicine Class :: #N/A 

Indications for Drugs ::

Opioid dependence, Opioid overdosage, Opioid-induced depression

Drug Dose ::

Adult: As hydrochloride: 200 mg to 3 g daily. Intravenous Opioid overdosage Adult: As hydrochloride: 0.4-2 mg repeated if necessary at 2-3 min intervals. If there is no response after a total of 10 mg has been given, consider the possibility of overdosage with other drugs. Reduce dose for opioid-dependent patients: 0.1-0.2 mg. IM/SC routes may be used (at IV doses) if IV admin is not feasible. Child: As hydrochloride: Initially 10 mcg/kg IV followed by 100 mcg/kg IV if necessary. Alternatively, 0.4-0.8 mg IM or SC, repeated as necessary, if IV admin is not feasible. Parenteral Opioid-induced depression in neonates due to obstetric analgesia Child: As hydrochloride: 10 mcg/kg IV, IM or SC repeated at 2-3 min intervals if necessary or 60 mcg/kg as a single IM dose. Intravenous Reversal of central depression from opioid use during surgery Adult: As hydrochloride: 100-200 mcg at intervals of 2-3 minute, titrate dose according to response while maintaining analgesia. Child: As hydrochloride: 5-10 mcg IV at 2-3 min intervals.

Contraindication ::

Hypersensitivity.

Drug Precautions ::

Patients physically dependent on opioids, or who have received large doses of opioids (acute withdrawal syndrome may be precipitated). Pregnancy and lactation.

Drug Side Effects ::

Occur secondarily to reversal (withdrawal) of narcotic analgesia and sedation. Mental depression, apathy, inability to concentrate, sleepiness, irritability, anorexia, nausea, and vomiting in high oral doses during initial treatment of opiate addiction. Potentially Fatal: Severe cardiopulmonary effects (e.g. hypotension, hypertension, ventricular tachycardia and fibrillation, dyspnoea, pulmonary oedema, cardiac arrest) in postoperative patients, most frequently in those with preexisting CV disease. Recurrence of respiratory depression in long-acting opioids.

Pregnancy category ::

3

Drug Mode of Action ::  

Naloxone is a pure opioid antagonist that acts competitively at opioid receptors.

Drug Interactions ::

Decreased effect of opioid analgesics. Potentially Fatal: Acute withdrawal reaction in physically dependent patients may occur with opioid analgesics. Severe cardiopulmonary effects may occur with cardiotoxic drugs.