The Brand Name NICOTEX-2 CHEWING GUM Has Generic Salt :: NICOTINE 

NICOTEX-2 CHEWING GUM  Is From Company Cipla Priced :: Rs. 40

NICOTEX-2 CHEWING GUM have NICOTINE is comes under Sub class Drugs for Substance Abuse of  Main Class Nervous System

Main Medicine Class:: Nervous System  Sub Medicine Class :: Drugs for Substance Abuse 

Indications for Drugs ::

Smoking cessation

Drug Dose ::

Adult: Buccal Chewing gum: Smokers of >20 cigarettes/day: Initial: Chew 4 mg gum when the urge to smoke occurs; reduce to 2 mg gum when possible. Smokers of >20 cigarettes/day: Start w/ 2 mg gum. Max: >15 pieces of either strengths/day. Loz: Initial: 1 loz 1-2 hrly. Max: 30 mg/day. Sublingual tabs: Per tab contains 2 mg of nicotine as ?-cyclodextrin complex): 1-2 tab/hr. Max: 40 tab/day. Reduce dose gradually until no longer needed. Smoking reduction As 2 or 4 mg gum: Chew 1 piece when urge occurs between smoking episodes; reduce smoking w/in 6 wk and attempt smoking cessation w/in 6 mth. Transdermal 1 patch for 16 or 24 hr daily. Start w/ the highest strength and reduce gradually over several wk to lower strengths. Lighter smokers may start w/ lower strength patches. Nasal As 500 mcg spray: 1 spray into each nostril when needed. Max: Twice/hr and 64 sprays/day. Reduce usage gradually until no longer needed. Inhalation As inhaler w/ 10 mg catridge: Inhale when urge occurs. Initial: 6-12 cartridges/day, reduce gradually till no longer needed. As inhaler w/ 10 mg cartridge: Inhale when urge to smoke occurs between smoking episodes; reduce smoking w/in 6 wk and attempt smoking cessation w/in 6 mth.

Contraindication ::

Nonsmokers, children and occasional smokers. Recent cerebrovascular accident, acute MI, unstable or worsening angina pectoris, severe cardiac arrhythmias, active temporomandibular joint disease (gum).

Drug Precautions ::

Use with caution in oropharyngeal inflammation and in patients with cerebrovascular disease, heart failure and renal impairment. History of oesophagitis, peptic ulcer, CV disease, hyperthyroidism, hepatic dysfunction; myasthenia gravis; DM (monitor blood glucose concentrations); pregnancy, lactation; peripheral vascular disease; skin disease (should not be applied on broken skin).

Drug Side Effects ::

Headache, cold and flu-like symptoms; insomnia; nausea; myalgia and dizziness; palpitations; dyspepsia, hiccups; vivid dreams; chest pain; anxiety and irritability; somnolence and impaired concentration; abnormal hunger; dysmenorrhoea; rash. Patches: Skin reactions (discontinue if severe), vasculitis. Spray: Nasal irritation, nose bleeds, watery eyes, ear sensations. Gum, lozenges, SL tab or inhalator: Apthous ulceration, throat irritation. Inhalator: Cough, rhinitis, pharyngitis, stomatitis, sinusitis, dry mouth.

Pregnancy category ::

4

Drug Mode of Action ::  

Nicotine is a potent ganglionic and CNS stimulant. It paralyses all autonomic ganglia after stimulation of the respiratory system (a central effect of small doses). Larger doses produce medullary-type convulsions then paralysis. The actions of nicotine are mediated via nicotine-specific receptors.

Drug Interactions ::

Nicotine increases the haemodynamic and AV blocking effects of adenosine. Monitor for treatment-emergent hypertension in patients treated with combination of nicotine patch and bupropion. Smoking cessation may increase response to various drugs e.g. theophylline, imipramine, oxazepam, pentazocine, some beta-blockers; monitor for increased toxicity.