The Brand Name NISPAM Has Generic Salt :: Pralidoxime
NISPAM Is From Company Neiss Priced :: Rs. 320
NISPAM have Pralidoxime is comes under Sub class Toxicity and Poison Management (Antidotes) of Main Class Toxicity and Poison Management (Antidotes)
Main Medicine Class:: Toxicity and Poison Management (Antidotes) Sub Medicine Class :: Toxicity and Poison Management (Antidotes)
|Salt Name : OR Generic Name||Form||Price : MRP /Probable||Packing|
Indications for Drugs ::
Drug Dose ::
Adult: IV/IM Used in combination w/ atropine. As Cl, iodide or mesilate: Upon atropinisation, administer 1-2 g, repeat dose after 1 hr, then 8-12 hrly if needed. Severe: 200-500 mg/hr via continuous infusion, titrate according to response. Max: 12 g/24 hr. Child: IV loading dose followed by continuous infusion 20-50 mg/kg/dose (not to exceed 2 g/dose) infused IV over 15-30 minutes Maintenance: 10-20 mg/kg/hr IV continuous infusion. IM administration <40 kg: 15 mg/kg/dose IM x3 doses 40 kg or greater: Administer as in adults; 600 mg/dose IM x3 doses. Contraindication ::
Carbamate pesticide poisoning, hypersensitivity.
Drug Precautions ::
Renal dysfunction, myasthenia gravis. Atropinisation may occur faster when atropine and pralidoxime are used together. Pregnancy, lactation.
Drug Side Effects ::
Drowsiness, dizziness, visual disturbances, nausea, tachycardia, headache, hyperventilation and muscle weakness. Potentially Fatal: Rapid admin causes tachycardia, laryngospasm and rigidity. Large doses cause neuromuscular blockade.
Pregnancy category ::
Drug Mode of Action ::
Pralidoxime reactivates cholinesterase outside the CNS which has been inactivated by phosphorylation due to organophosphate pesticide exposure-resulting. This leads to the destruction of acetylcholine at the neuromuscular junction thus relieving muscle paralysis. It also removes the phosphyl group from the active site of inactivated enzyme which is dependent on the nature of the phosphyl group.
Drug Interactions ::