Article Contents ::
Details About Generic Salt :: Nitrazepam
Main Medicine Class:: Nervous System Sub Medicine Class :: Sedatives , Hypnotics
| 1C. ANTI-EPILEPTICS in 1. NERVOUS SYSTEM |
| NITRAZEPAM |
| BENZODIAZEPINE | SEDATIVE & HYPNOTIC, ANTI-EPILEPTIC |
| also comes under 1A. Sedatives & Hypnotics in 1. Nervous System, |
| PK: A: Rapid D: 2.4L/Kg (Vd) M: Hepatic E: Urine (65%-70%), feces (14%-20%) |
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Indications & Dose: INSOMNIA Short-term therapy PO Adult 5-10mg HS Elderly 2.5–5mg HS | MYOCLONIC SEIZURES PO Child <30 kg: 0.3-1mg/kg/day TID |
| Contra: Porphyria, myasthenia gravis, narrow angle glaucoma, severe respiratory insufficiency, sleep apnea syndrome, severe hepatic impairment
Precautions: Respiratory disease, muscle weakness, history of drug/alcohol abuse, elderly/debilitated patients, renal impairment ADR: Serious: Hypotension, blurred vision, psychoses, Others: aspiration, granulocytopenia, muscle weakness, constipation, diarrhea, nightmares, palpitation, delusion, change in libido, headache, irritability DDI: Serious Rifampicin increases drug clearance, Hormonal Contraceptives increases drug effect, Primidone levels are reduced in children Diet: Monitor: Respiratory & cardiovascular status |
