Article Contents ::
- 1 The Brand Name NOBLIGAN Has Generic Salt :: Tramadol
- 2 NOBLIGAN Is From Company Nicholas Priced :: Rs. 141.16
- 3 NOBLIGAN have Tramadol is comes under Sub class #N/A of Main Class #N/A
- 4 Main Medicine Class:: #N/A Sub Medicine Class :: #N/A
- 5 Disclaimer ::
The Brand Name NOBLIGAN Has Generic Salt :: Tramadol
NOBLIGAN Is From Company Nicholas Priced :: Rs. 141.16
NOBLIGAN have Tramadol is comes under Sub class #N/A of Main Class #N/A
Main Medicine Class:: #N/A Sub Medicine Class :: #N/A
|Salt Name : OR Generic Name||Form||Price : MRP /Probable||Packing|
|Tramadol||SR TAB||Rs. 141.16||10|
Indications for Drugs ::
Moderate to severe pain, Postoperative pain
Drug Dose ::
Adult: PO Moderate to severe pain 50-100 mg 4-6 hrly. Max: 400 mg/day. Extended-release 50-100 mg 1-2 times/day. Max: 300 mg/day. Renal impairment: CrCl (ml/min) <10 Contraindicated. 10 to <30 Increase dosing interval to 12hrly. Max: 200 mg/day; Contraindicated (extended-release tab). Hepatic impairment: Severe: Increase dosing interval to 12 hrly; Contraindicated (extended-release). IV/IM Moderate to severe pain 50-100 mg 4-6 hrly. Post-op pain Initial: 100 mg, then 50 mg every 10-20 mins if needed, up to 250 mg for the 1st hr. Maintenance: 50-100 mg 4-6 hrly. Max: 600 mg/day. Rectal Moderate to severe pain As 100 mg supp: 1 supp up to 4 times/day. Elderly: >75 yr Increase dosing interval. Renal impairment: CrCl (ml/min) 10-30 Increase dosing interval to 12 hrly. <10 Contraindicated. Hepatic impairment: Severe: increase dosing interval to 12 hrly. Contraindication ::
Suicidal patients, acute alcoholism; head injuries; raised intracranial pressure; severe renal impairment; lactation.
Drug Precautions ::
Hypothyroidism; adrenocortical insufficiency; renal or hepatic impairment; history of epilepsy or increased risk of seizures; inflammatory or obstructive bowel disease; myasthaenia gravis; respiratory depression; prostatic hyperplasia. Pregnancy.
Drug Side Effects ::
Sweating, dizziness, nausea, vomiting, dry mouth, fatigue, asthenia, somnolence, confusion, constipation, flushing, headache, vertigo, tachycardia, palpitations, miosis, insomnia, orthostatic hypotension, seizures, CNS stimulation e.g. hallucinations. Potentially Fatal: Respiratory depression.
Pregnancy category ::
Drug Mode of Action ::
Tramadol inhibits reuptake of norepinephrine, serotonin and enhances serotonin release. It alters perception and response to pain by binding to mu-opiate receptors in the CNS.
Drug Interactions ::
Increased risk of convulsions or serotonin syndrome w/ SSRI, serotonin-norepinephrine reuptake inhibitors (SNRI), TCA and other seizure threshold lowering drugs (e.g. bupropion, mirtazapine, tetrahydrocannabinol). Decreased serum concentrations w/ carbamazepine. May potentiate the anti-depressant effect of norepinephrine, 5-HT agonists or lithium. Increased INR and ecchymoses w/ coumarin derivatives (e.g. warfarin). Potentially Fatal: Increased risk of seizure and serotonin syndrome w/ MAOIs.