The Brand Name NORMADATE Has Generic Salt :: Labetalol
NORMADATE Is From Company Gsk Priced :: Rs. 54.23
NORMADATE have Labetalol is comes under Sub class Miscellaneous of Main Class Anti Infectives
Main Medicine Class:: Anti Infectives Sub Medicine Class :: Miscellaneous
|Salt Name : OR Generic Name||Form||Price : MRP /Probable||Packing|
Indications for Drugs ::
Hypertension, Hypotensive anaesthesia
Drug Dose ::
Adult: PO HTN Initial: 100 mg twice daily, up to 200-400 mg twice daily. Max: 2.4 g/day in 2-4 divided doses. IV Emergency treatment of HTN 50 mg, repeat at 5-min intervals if needed, up to a total dose of 200 mg. HTN in pregnancy Initial: 20 mg/hr, double dose every 30 mins until a favourable response or a dose of 160 mg/hr is reached. HTN after MI Initial: 15 mg/hr, may increase slowly until a favourable response or a dose of 120 mg/hr is achieved. Hypotensive anesth Initial: 10-20 mg, may increase slowly if satisfactory hypotension is not reached after 5 mins.
2nd and 3rd degree heart block, cardiogenic shock, obstructive airway disease e.g. bronchial asthma, uncompensated heart failure, severe bradycardia, sick sinus syndrome, Prinzmetal’s angina, severe peripheral arterial disease.
Drug Precautions ::
Phaeochromocytoma, compensated heart failure, nonallergic bronchospasm. Avoid abrupt withdrawal. DM. Hepatic impairment. Perform LFTs. Elderly. Pregnancy and lactation.
Drug Side Effects ::
Orthostatic hypotension, dizziness, fatigue, vertigo, paraesthesia, headache, nasal stuffiness, dyspnoea, diarrhoea, abdominal pain, sexual dysfunction, dyspepsia, nausea, vomiting, scalp tingling, rash, increased transaminases, nightmares, worsening of intermittent claudication. Potentially Fatal: Hepatic injury.
Pregnancy category ::
Drug Mode of Action ::
Labetalol competitively inhibits the adrenergic stimulation of ?-receptors w/in the myocardium, bronchial and vascular smooth muscle, and ?1-receptors w/in vascular smooth muscle. It also has some intrinsic ?2-agonist and membrane-stabilising activity.
Drug Interactions ::
Synergistic hypotensive effect w/ halothane. Increased absolute bioavailability w/ cimetidine. Decreased absolute bioavailability w/ glutethimide. Additive hypotensive effect w/ nitroglycerin. Increased incidence of tremor w/ TCAs. Increased risk of bradycardia and heart block w/ Ca channel blocker (e.g. verapamil, diltiazem).