The Brand Name OCLEAN Has Generic Salt :: Timolol 

OCLEAN  Is From Company Cosme Hc. Priced :: Rs. 27

OCLEAN have Timolol is comes under Sub class #N/A of  Main Class #N/A

Main Medicine Class:: #N/A  Sub Medicine Class :: #N/A 

Indications for Drugs ::

Open-angle glaucoma, Ocular hypertension

Drug Dose ::

Ophth Open-angle glaucoma; Ocular HTN As eye drop soln: Initial: Instill 1 drop of 0.25% soln to affected eye(s) twice daily, increase to 1 drop of 0.5% soln twice daily if needed. Reduce to 1 drop/day if controlled.

Contraindication ::

Present or history of bronchial asthma, severe COPD, sinus bradycardia, 2nd and 3rd degree heart block, sick sinus syndrome, overt heart failure, cardiogenic shock, severe peripheral vascular disease/Raynaud’s disease), Prinzmetal angina, untreated pheochromocytoma, metabolic acidosis, hypotension.

Drug Precautions ::

Due to systemic absorption of ophthalmic preparations, adverse reactions associated with systemic administration of beta-blockers may occur. Abrupt withdrawal of beta-blocker may cause exacerbation of angina, and myocardial infarctions have occurred in some cases. Ophthalmic Timolol should not be used alone for treatment of angle-closure glaucoma. beta-blocker therapy may increase sensitivity towards allergen in patients with history of atrophy or severe anaphylaxis reactions. Safety and efficacy have not been established in paediatric patients.

Drug Side Effects ::

Ophthalmic use: Burning, stinging, blurred vision, ocular irritation (e.g. conjunctivitis, blepharitis, crusting), decreased corneal sensitivity, visual disturbances, diplopia, ptosis, cystoid macular oedema, pseudopemphigoid, choroidal detachment following filtration surgery. Adverse reactions associated with systemic administration of beta-blocker may occur with ophthalmic use. Potentially Fatal: Heart failure, intensification of heart block, bronchospasm, respiratory failure.

Pregnancy category ::

3

Drug Mode of Action ::  

Exact mechanism of ocular hypotensive effect is unclear, but it is thought to be related to reduction of aqueous humour formation. beta-blockade also causes lowering of BP.

Drug Interactions ::

Concomitant admin w/ reserpine may increase hypotension and bradycardia. Additive effects w/ other antihypertensives (e.g. hydralazine, methyldopa). Increased ?-adrenergic blockade (e.g. decreased heart rate) w/ quinidine. Rebound HTN due to abrupt withdrawal of clonidine. Hypotensive effect may be antagonised by NSAIDs (e.g. indomethacin, ibuprofen).