The Brand Name OF Has Generic Salt :: Ofloxacin 

OF  Is From Company J. B. Chem. Priced :: Rs. 21

OF have Ofloxacin is comes under Sub class Quinolones of  Main Class Anti Infectives

Main Medicine Class:: Anti Infectives  Sub Medicine Class :: Quinolones 

Indications for Drugs ::

Leprosy,chronic bronchitis; Community-acquired pneumonia; Uncomplicated skin infections,anthrax,Legionnaire’s disease,Nongonococcal cervicitis; Urethritis, Uncomplicated cystitis, Complicated UTI, Traveller’s diarrhea, bacterial prostatis, Typhoid fever, Skin and soft tissue infections, Uncomplicated gonorrhea, Pelvic inflammatory disease, Lower respiratory tract infections, Septicaemia

Drug Dose ::

Adult: PO Part of multidrug therapy in leprosy 400 mg/day or intermittently, depending on regimen. Uncomplicated gonorrhoea Single dose of 400 mg. Acute bacterial exacerbation of chronic bronchitis; Community-acquired pneumonia; Uncomplicated skin infections 400 mg twice daily for 10 days. Pelvic inflammatory disease 400 mg twice daily for 14 days. Postexposure prophylaxis following exposure to inhalational anthrax 400 mg twice daily for 60 days. Legionnaire’s disease 400 mg twice daily for 2-3 wk. Mixed infection of the urethra and cervix due to C. trachomatis and Neisseria gonorrhoeae; Nongonococcal cervicitis; Urethritis due to Chlamydia trachomatis 200-300 mg twice daily for 7 days. Uncomplicated cystitis 200 mg twice daily for 3-7 days. Duration depends on causative agent. Complicated UTI 200 mg twice daily for 10 days. Traveller’s diarrhoea 300 mg twice daily for 1-3 days. Chronic bacterial prostatis 300 mg twice daily for 6 wk. Typhoid fever 200-400 mg twice daily for 7-14 days. Intravenous Adult: 200 mg daily by IV infusion over at least 30 min. Max: 400 mg bid infused over at least 1 hr. Renal impairment: Initial dose as normal then reduce. CrCl (ml/min) 20-50 Reduce dose by half or give usual dose only every 24 hr. <20 100 mg every 24 hr. Hepatic impairment: Clearance is reduced in severe hepatic impairment, lower doses should be used. Max: 400 mg daily. Contraindication ::

Hypersensitivity to quinolones; pregnancy and lactation; prolongation of the QT interval; uncorrected hypokalaemia.

Drug Precautions ::

Epilepsy or other predisposition to seizures; known or suspected CNS disorders; renal, hepatic impairment; myasthaenia gravis; superinfection; children <18 yr; exposure to strong sunlight and UV light; ensure adequate hydration; elderly. Drug Side Effects ::

Nausea, vomiting, abdominal pain, diarrhoea; headache, dizziness, insomnia, hallucinations; leucopenia and eosinophilia; vaginitis; dysgeusia; tendon damage and rupture; anorexia; tremor; photosensitivity; hypersensitivity reactions. Discontinue if psychiatric, neurological or hypersensitivity reactions occur. Potentially Fatal: Anaphylaxis; rarely seizures.

Pregnancy category ::

3

Drug Mode of Action ::  

Ofloxacin is a fluoroquinolone which inhibits bacterial topoisomerase IV and DNA gyrase enzymes required for DNA replication, transcription, repair and recombination. It has activity against a wide range of gram-negative and gram-positive microorganisms.

Drug Interactions ::

Concomitant use of class IA (e.g. quinidine, procainamide) or class III (e.g. amiodarone, sotalol) antiarrhythmic agents may increase risk of QT interval prolongation. Decreased serum and urine concentrations w/ antacids containing Mg, Al or Ca. Additive antibacterial activity w/ aminoglycosides (e.g. amikacin, tobramycin). Corticosteroids may increase risk of severe tendon disorders. Increased risk of CNS stimulation (e.g. seizures) w/ NSAIDs. Higher and prolonged serum theophylline concentrations and increased risk of theophylline-related adverse effects.