The Brand Name OKAMYCIN Has Generic Salt :: Erythromycin 

OKAMYCIN  Is From Company Cipla Priced :: Rs. 33

OKAMYCIN have Erythromycin is comes under Sub class Macrolides of  Main Class Anti Infectives

Main Medicine Class:: Anti Infectives  Sub Medicine Class :: Macrolides 

Indications for Drugs ::

Susceptible infections, Respiratory tract infections, Enteritis, Pertussis, Trench fever, Chanroid, Chlamydial infections, Diphtheria, Legionnaire’s disease, Pneumonia, Sinusitis, Bronchitis, Acne, Rheumatic fever, Neonatal conjunctivitis.

Drug Dose ::

Adults: Usually 250 mg every 6 hours, or 500 mg every 12 hours. May increase up to 4 g/day, according to severity of infection. Upper respiratory tract infections of mild to moderate severity: 250 to 500 mg 4 times a day for 10 days. Lower respiratory infections of mild to moderate severity: 250 to 500 mg 4 times a day for 10 days. Respiratory tract infections due to Mycoplasma pneumoniae: 500 mg 6 hours for 5 to 10 days, treat severe infections for up to 3 weeks. Skin and soft tissue infections of mild to moderate severity: 250 to 500 mg 4 times a day for 10 days. Pelvic inflammatory diseases (PID), acute due to Neisseria gonorrhoeae: 500 mg 4 times a day for 10 to 14 days. Urogenital infection during pregnancy caused by Chlamydia trachomatis: 500 mg 4 times daily for 7 days or 250 mg 4 times daily for 14 days. Urethral, endocervical or rectal infections, uncomplicated: 500 mg 4 times daily for 7 days or 250 mg 4 times daily for 14 days. Non-gonococcal urethritis: 500 mg 4 times daily for at least 7 days. Neisseria gonorrhoeae: Uncomplicated urethral, endocervical or rectal infections and in penicillinase producing N. gonorrhoeae(PPNG): 500 mg 4 times a day for 7 days. Early syphillis (primary, secondary or latent syphillis of < 1 year duration): 500 mg 4 times a day for 14 days. Severe or chronic diarrhoea: 500 mg 4 times a day for 7 days. Rheumatic fever: 250 mg 2 times daily. Bacterial endocarditis: 1 g 2 hours prior to procedures, then 500 mg 6 hours after initial dose. Acne: 500 mg twice daily for 3 months reduced to 250 mg twice for 3 months. Children: The usual oral dose is 30-50 mg/kg body weight per day in divided doses. For more severe infections, the dose may be doubled. Contraindication ::

Hypersensitivity; porphyria; hepatic impairment; pregnancy.

Drug Precautions ::

Increased risk of cholestatic hepatitis when treatment is >10 days or in patients with previous history of erythromycin usage. History of hepatic disorders; arrhythmias; prolonged QT interval; lactation. Monitor liver function. Avoid estolate in liver impairment. Caution when using lactobionate in patients with severe renal impairment. May aggravate muscle weakness in patients with myasthenia gravis.

Drug Side Effects ::

Rash, urticaria; nausea, vomiting, GI discomfort; ototoxicity; central neurotoxicity; agranulocytosis; arrhythmias; pancreatitis. Potentially Fatal: Hepatotoxicity, cholestatic jaundice; raised serum transaminases; eosinophilia.

Pregnancy category ::

2

Drug Mode of Action ::  

Erythromycin inhibits protein synthesis by irreversibly binding to the 50S ribosomal subunit thus blocking the transpeptidation or translocation reactions of susceptible organisms resulting in stunted cell growth.

Drug Interactions ::

May decrease plasma levels of valproic acid thus, increasing the risk of seizures. Increased plasma concentrations w/ probenecid.