Article Contents ::
Details About Generic Salt :: Orlistat
Main Medicine Class:: Endocrine,Steroid Hormones , Metabolic System Sub Medicine Class :: Anti Obesity Drugs
| 8J. ANTI-OBESITY DRUGS in 8. ENDOCRINE/STEROID HORMONES & METABOLIC SYSTEM |
| ORLISTAT |
| LIPASE INHIBITOR | ANTI-OBESITY |
| PK: A: Minimal M: Intestine E: Feces (97%), urine(<2%) |
|
Indications & Dose: OBESITY PO Adult 120mg TID with each main meal containing fat and it includes for weight loss & management, when used in conjunction with a reduced-calorie & low-fat diet |
| Contra: Hypersensitivity, chronic malabsorption syndrome/cholestasis
Precautions: History of hyperoxaluria/calcium oxalate nephrolithiasis, type II DM ADR: Serious: HTN, Others: GI disturbances, fecal urgency & incontinence, flatulence, fatty stools/discharge, anxiety, fatigue, menstrual irregularities, increased risk of breast cancer, headache DDI: Serious Vit E/Amiodarone absorption reduced, Coumarins absorption reduced that leads to increase in INR, ACEIs increases in BP, Hormonal Contraceptives risk of contraceptive failure is increased Diet: Monitor: BMI, diet (calorie & fat intake), serum glucose, TFT, LFTs |
