The Brand Name ORTHOBID Has Generic Salt :: Nimesulide 

ORTHOBID  Is From Company Nicholas Priced :: Rs. 29.19

ORTHOBID have Nimesulide is comes under Sub class Analgesics , Anti inflammatory Drugs of  Main Class Musculoskeletal Disorders , Pain

Main Medicine Class:: Musculoskeletal Disorders , Pain  Sub Medicine Class :: Analgesics , Anti inflammatory Drugs 

Indications for Drugs ::

Acute pain; Extra-articular disorders; Osteoarthritis; Post-op pain; Primary dysmenorrhoea

Drug Dose ::

Adult: PO Acute pain; Extra-articular disorders; Osteoarthritis; Post-op pain; Primary dysmenorrhoea 100 mg twice daily.

Contraindication ::

Hypersensitivity; GI bleeding, active peptic ulcer disease; severe renal and heart failure; hepatic impairment or known liver disease; coagulation disorders; pregnancy; children <12 yr. Drug Precautions ::

History of GI tract disease, infections, oedema, hypertension, elderly, lactation.

Drug Side Effects ::

Epigastric discomfort, heartburn or abdominal cramps, nausea, vomiting and diarrhoea; skin rash, pruritus, oedema, headache, dizziness, drowsiness; hypersensitivity reactions (e.g. bronchospasm, rhinitis, angioedema urticaria); GI haemorrhage/perforation; bullous/erosive stomatitis, purpura, thrombocytopenia, toxic epidermal necrolysis, haematuria, oliguria, and renal failure; increases in liver enzymes. Potentially Fatal: Fatal hepatitis, Stevens Johnson syndrome.

Pregnancy category ::

0

Drug Mode of Action ::  

Nimesulide is a nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, anti-pyretic, and analgesic properties. It inhibits prostaglandin synthetase/cyclooxygenase, which limits prostaglandin production. Its cyclooxygenase inhibiting potency is intermediate, but is relatively selective for the cyclo-oxygenase-2 (COX-2) thus the potential for gastric injury and intolerance is less. It is also a free radical scavenger, and helps protect against the tissue damage that occurs during inflammation.

Drug Interactions ::

Additive hepatotoxic effects with known hepatotoxins: anti-convulsants (e.g. valproic acid), anti-fungals (e.g. ketoconazole), anti-tuberculous drugs (e.g. isoniazid), tacrine, pemoline, amiodarone, methotrexate, methyldopa, amoxicillin/clavulanic acid. May decrease the oral bioavailability of furosemide and the natriuretic and diuretic response to furosemide. Increased risks of GI and hepatic adverse effects with other NSAIDs, including aspirin. May increase anti-coagulant effect of warfarin. Potentiates the action of phenytoin. May be displaced from binding sites with fenofibrate, salicylic acid, and tolbutamide. Interactions between NSAIDs and lithium, probenecid and ciclosporin, have been documented.