The Brand Name OXAPRO Has Generic Salt :: OXAPROZIN 

OXAPRO  Is From Company Zuventus Priced :: Rs. 62

OXAPRO have OXAPROZIN is comes under Sub class #N/A of  Main Class #N/A

Main Medicine Class:: #N/A  Sub Medicine Class :: #N/A 

Indications for Drugs ::

Rheumatoid arthritis, Osteoarthritis, Juvenile rheumatoid arthritis

Drug Dose ::

Adult: PO Osteoarthritis 1.2 g once daily. Patients w/ low body wt or mild disease: Initial: 600 mg once daily. Max: 1.8 g or 26 mg/kg (whichever is lower) in divided doses. Rheumatoid arthritis 1.2 g once daily. Max: 1.8 g or 26 mg/kg (whichever is lower) in divided doses. Juvenile rheumatoid arthritis Child: >6 yr: Wt 22-31 kg: 600 mg; 32-54 kg: 900 mg; >55 kg: 1200 mg. All doses to be given once daily.

Contraindication ::

Previous or active peptic ulceration, known hypersensitivity to NSAIDs. Perioperative pain in CABG setting.

Drug Precautions ::

Be alert for ulceration and bleeding in patients treated chronically. History of serious GI events, alcoholism, smoking, other factors known to be associated with peptic ulcer. Elderly or debilitated patients. Uncompensated cardiac failure, history of hypertension, cardiac decompensation, chronic diuretic therapy, conditions predisposing to fluid retention. Renal and hepatic impairment. Underlying coagulation defects or patients who are undergoing surgical procedures where a high degree of haemostasis is required. Pregnancy (avoid in 3rd trimester) and lactation.

Drug Side Effects ::

Depression, sedation, somnolence, confusion, disturbance of sleep, weakness, malaise; rash, prutitus, urticaria, photosensitivity; abdominal pain/distress, anorexia, flatulence, vomiting, constipation, diarrhoea, dyspepsia, nausea, peptic ulcer and/or GI bleeding, abnormalities in LFTs, stomatitis, haemorrhoidal or rectal bleeding; tinnitus; dysuria or frequency; oedema, BP changes; haematuria, renal insufficiency, decreased menstrual flow; anaemia, thrombocytopenia, leukopenia, ecchymoses; wt gain/loss; blurred vision, conjunctivitis. Potentially Fatal: Anaphylactoid reactions, exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, severe hepatic reactions.

Pregnancy category ::

4

Drug Mode of Action ::  

Oxaprozin is a propionic acid derivative NSAID. It inhibits the enzyme cyclooxygenase resulting in the blockage of prostaglandin synthesis.

Drug Interactions ::

Increased risk of salicylate toxicity with aspirin. May increase effects of oral anticoagulants. May reduce effects of ?-blockers, diuretics and other antihypertensive agents. May increase risk of methotrexate and lithium toxicity.