The Brand Name PARAPLATIN Has Generic Salt :: CARBOPLATIN 

PARAPLATIN  Is From Company BRISTOL MYERS Priced :: Rs. 4500

PARAPLATIN have CARBOPLATIN is comes under Sub class Anti Neoplastic Agents of  Main Class Anti Neoplastic Agents

Main Medicine Class:: Anti Neoplastic Agents  Sub Medicine Class :: Anti Neoplastic Agents 

Indications for Drugs ::

Ovarian carcinoma, Lung cancer

Drug Dose ::

Adult: IV As single agent in treatment-naive patients: 400 mg/m2; As single agent in previously treated patients: 360 mg/m2; W/ cyclophosphamide in treatment-naive patients: 300 mg/m2. Doses to be given not more frequently than every 4 wk. Adjust subsequent doses based on nadir of WBC and platelet counts. Renal impairment: CrCl (ml/min) >40 Recommended dose: 400 mg/m2. 20-39 Recommended dose: 250 mg/m2.

Contraindication ::

Previous allergy; pregnancy, lactation; allergy to other platinum compounds; severe bone marrow depression; significant bleeding, aluminium containing needles and IV sets.

Drug Precautions ::

Neonates; diminished renal function; neurotoxicity; liver function impairment.

Drug Side Effects ::

Thrombocytopenia, neutropenia, leukopenia, anaemia; nausea, vomiting, central neurotoxicity, peripheral neuropathies, ototoxicity; elevation of ALT, AST, blood urea and bilirubin levels, electrolyte disturbances; alopecia; asthenia, pain; cardiac failure, embolism and cerebrovascular accidents may occur; mucositis. Potentially Fatal: Bone marrow suppression and anaphylactic reactions.

Pregnancy category ::

4

Drug Mode of Action ::  

Carboplatin is an alkylating agent which binds covalently to DNA. It modifies the cell cycle by interfering with DNA structure and function.

Drug Interactions ::

Increased risk of ototoxicity when used with aminoglycosides.