The Brand Name PETHIDINE HCL Has Generic Salt :: Pethidine 

PETHIDINE HCL  Is From Company Haffkine Priced :: Rs. 489.45

PETHIDINE HCL have Pethidine is comes under Sub class #N/A of  Main Class #N/A

Main Medicine Class:: #N/A  Sub Medicine Class :: #N/A 

Indications for Drugs ::

Anaesthesia, Postoperative pain, Moderate to severe acute pain, Obstetric analgesia

Drug Dose ::

Adult: IV Adjunct to anesth 10-25 mg. IV/IM/SC Moderate to severe acute pain 25-100 mg IM/SC inj or 25-50 mg by slow IV inj repeated after 4 hr. IM/SC Obstetric analgesia 50-100 mg as soon as contractions occur at regular intervals; repeat after 1-3 hr if needed. Max: 400 mg/24 hr. Pre-op medication 25-100 mg 1 hr pre-op. Post-op pain25-100 mg 2-3 hrly if needed.

Contraindication ::

Hypersensitivity.

Drug Precautions ::

May impair ability to drive or operate machinery. Hypovolaemia, CV disease; adrenal insufficiency; biliary tract disorder; CNS depression or coma; history of drug abuse or acute alcoholism; head injury, intracranial lesions, elevated intracranial pressure; hepatic or renal impairment; morbidly obese; prostatic hyperplasia; toxic psychoses; pre-existing respiratory compromise (hypoxia and/or hypercapnia), COPD or other obstructive airway disease; sickle-cell disease; supraventricular tachycardia; thyroid dysfunction. Elderly and debilitated patients. Withdraw gradually. Pregnancy (avoid prolonged use or high doses at term) and lactation.

Drug Side Effects ::

Hypotension; fatigue, drowsiness, dizziness, nervousness, headache, restlessness, malaise, confusion, depression, hallucinations, tremors, muscle twitches, increased intracranial pressure, seizure, serotonin syndrome; rash, urticaria; nausea, vomiting, constipation, anorexia, stomach cramps, xerostomia, biliary spasm, paralytic ileus, sphincter of Oddi spasm; ureteral spasms, decreased urination; pain at inj site; weakness; dyspnoea; histamine release, physical and psychological dependence.

Pregnancy category ::

4

Drug Mode of Action ::  

Pethidine is a phenylpiperidine derivative opioid analgesic. It acts mainly as mu-receptor agonist. Like most, opioid analgesics, it mimics endogenous opioids by activating opioid receptors in the central and peripheral nervous system. It reduces the release of neurotransmitter substances and also reduces the activity of postsynaptic neurons in the spinal cord thus preventing transmission of pain impulse.

Drug Interactions ::

W/in 2 wk of MAOIs or moclobemide, selegiline, ritonavir, cimetidine, CNS depressants, barbiturate salts, aminophylline, heparin, methicillin, morphine, nitrofurantoin, phenytoin, sulphadiazine, Na iodide, sulphafurazole diethanolamine, acyclovir, imipenem, frusemide, idarubicin, minocycline, tetracycline, cefoperazone, mezlocillin, nafcillin, liposomal doxorubicin.