The Brand Name POWERCEF Has Generic Salt :: Ceftriaxone 

POWERCEF  Is From Company Wockhardt Priced :: Rs. 25

POWERCEF have Ceftriaxone is comes under Sub class Cephalosporins of  Main Class Anti Infectives

Main Medicine Class:: Anti Infectives  Sub Medicine Class :: Cephalosporins 

Indications for Drugs ::

Pneumonia, Meningitis, Acute otitis media, Lyme disease, Typhoid fever, Otitis media, Pelvic inflammatory disease, Septicemia, Skin and Skin-Structure Infections, Gonorrhea, Respiratory tract infections, Urinary tract infections, Bone and Joint Infections, Chlamydia infection, Surgical Prophylaxis

Drug Dose ::

Adult: IV Typhoid fever 2 g once daily for 14 days. IV/IM Susceptible infections 1-2 g/day, up to 4 g/day for severe infections. Surgical prophylaxis 1 g as a single dose 0.5-2 hr pre-op. IM Uncomplicated gonorrhoea; Prevention of secondary meningococcal meningitis 250 mg as a single dose. Children under 12 years: The recommended total daily dose is 50 to 75 mg/kg once daily (or twice daily in equally divided doses). In severe infections, up to 80 mg/kg body weight daily may be given. The total daily dose should not exceed 2 gm. In the treatment of meningitis, the initial dose of 100 mg/kg body weight (not to exceed 4 gm daily) once daily (or twice daily in equally divided doses), is recommended. As soon as the causative organism has been identified and its sensitivity, the doses can be reduced accordingly. The usual duration of therapy in meningitis is 7 to 14 days. Renal impairment: CrCl (ml/min) <10 Max: 2 g daily. Contraindication ::

Hypersensitivity to cephalosporins; hyperbilirubinaemic neonates. Do not use calcium or calcium-containing solutions or products with or within 48 hr of ceftriaxone administration due to risk of calcium-ceftriaxone precipitate formation.

Drug Precautions ::

History of penicillin allergy; severe renal impairment; pregnancy and lactation; superinfection.

Drug Side Effects ::

History of penicillin allergy; severe renal impairment; pregnancy and lactation; superinfection.

Pregnancy category ::

2

Drug Mode of Action ::  

Ceftriaxone binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.

Drug Interactions ::

May increase nephrotoxicity of aminoglycosides. May diminish therapeutic effect of BCG, typhoid vaccine, Na picosulfate. May increase anticoagulant effect of vit K antagonists (e.g. warfarin). May increase serum level w/ probenecid. Potentially Fatal: Admin w/ Ca-containing IV soln may cause precipitation of a crystalline material in the lungs and kidneys.