Article Contents ::
Details About Generic Salt :: Pregabalin
Main Medicine Class:: Nervous System Sub Medicine Class :: Anti Epileptics
| 1J. DRUGS FOR NEUROPATHIC PAIN in 1. NERVOUS SYSTEM |
| PREGABALIN |
| GABA DERIVATIVE | ANTI-EPILEPTIC, ANXIOLYTIC |
| also comes under 1C. Anti-Epileptics in 1. Nervous System, 1B. Anxiolytics in 1. Nervous System |
| PK: A: Rapid D: 0.5L/kg (Vd) E: Urine (90%) |
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Indications & Dose: ANXIETY PO Adult Initially 150mg/day in 2–3 divided doses, increase if necessary at 7-day intervals in steps of 150mg/day, max 600mg/day in 2–3 divided doses | FIBROMYALGIA PO Adult Initially 150mg/day, increase to 300mg/day after 1 wk according to response, followed by 450mg/day | PARTIAL SEIZURES WITH/ WITHOUT SECONDARY GENERALIZATION Adjunct therapy PO Adult Initially 25mg BID, increase at 7-day intervals in steps of 50mg-300mg/day in 2–3 divided doses, increase further after 7 days to max 600mg/day in 2–3 divided doses | PERIPHERAL & CENTRAL NEUROPATHIC PAIN PO Adult Initially 150mg/day in 2–3 divided doses, increase if needed after 3–7 days to 300mg/day in 2–3 divided doses, increase further after 7 days to max 600mg/day in 2–3 divided doses |
| Contra: Hypersensitivity
Precautions: Avoid abrupt withdrawal, CRF, CHF ADR: Serious: First-degree AV block, arrhythmia, dysuria, thrombocytopenia, joint swelling, pancreatitis, hypotension, hypoglycaemia, rhabdomyolysis, hypokalemia, CHF, angioedema, SJS, arthralgia, Others: pruritus, hyperglycemia, nausea, vomiting, constipation, drowsiness, flatulence, paresthesia, confusion, fatigue, diplopia, insomnia, myalgia DDI: Serious Lorazepam/Alcohol efficacy is increased, Oxcarbazepine/Carbamazepine/Phenytoin may reduce drug level Diet: With/without food Monitor: Symptoms of myopathy, skin integrity, weight gain, suicidality |
