The Brand Name PRONAC Has Generic Salt :: Acetylcysteine 

PRONAC  Is From Company Astrum Hc. Priced :: Rs. 40

PRONAC have Acetylcysteine is comes under Sub class Toxicity and Poison Management (Antidotes) of  Main Class Toxicity and Poison Management (Antidotes)

Main Medicine Class:: Toxicity and Poison Management (Antidotes)  Sub Medicine Class :: Toxicity and Poison Management (Antidotes) 

Indications for Drugs ::

Tuberculosis, Chronic emphysema, Paracetamol poisoning, Bronchiectasis, Pneumonia, Atelectasis, Cystic fibrosis, Tracheostomy care, during anaesthesia

Drug Dose ::

Oral As a mucolytic Adult: As effervescent granules or tablets: 200 mg tid. Child: As effervescent granules or tablets: 2-7 yr: 200 mg bid; <2 yr: 200 mg daily. Paracetamol poisoning Adult: After gastric lavage or induction of emesis with ipecac syrup, admin loading dose of 140 mg/kg, followed by maintenance doses of 70 mg/kg every 4 hr for a total of 17 doses. 1st maintenance dose to be given 4 hr after the loading dose. Repeat dose if the patient vomits within 1 hr of admin. Continue therapy until paracetamol levels are not detectable and there is no evidence of hepatotoxicity. Child: After gastric lavage or induction of emesis with ipecac syrup, admin loading dose of 140 mg/kg, followed by maintenance doses of 70 mg/kg every 4 hr for a total of 17 doses. 1st maintenance dose to be given 4 hr after the loading dose. Repeat dose if the patient vomits within 1 hr of admin. Continue therapy until paracetamol levels are not detectable and there is no evidence of hepatotoxicity. Inhalation As a mucolytic Adult: 3-5 ml of a 20% solution or 6-10 ml of a 10% solution 3-4 times daily by nebulising through a face mask, mouth piece or tracheostomy. May increase to 1-10 ml of a 20% solution or 2-20 ml of a 10% solution every 2-6 hr if needed. Child: 3-5 ml of a 20% solution or 6-10 ml of a 10% solution 3-4 times daily by nebulising through a face mask, mouth piece or tracheostomy. May increase to 1-10 ml of a 20% solution or 2-20 ml of a 10% solution every 2-6 hr if needed. Endotracheal As a mucolytic Adult: Instill 1-2 ml of a 10-20% solution as often as every hrly. Child: Instill 1-2 ml of a 10-20% solution as often as every hrly. Contraindication ::

Acetylcysteine is contraindicated in those patients who are sensitive to it.

Drug Precautions ::

Asthmatic patients, history of bronchospasm, peptic ulceration. Pregnancy, lactation.

Drug Side Effects ::

Flushing, fever, stomatitis, nausea, vomiting, rhinorrhoea, bronchospasm, anaphylactoid reactions, rashes. Rarely, blurred vision, bradycardia, syncope, thrombocytopenia, convulsions. Potentially Fatal: Rarely, respiratory or cardiac arrest.

Pregnancy category ::

2

Drug Mode of Action ::  

Acetylcysteine may decrease the viscosity of secretions by splitting of disulphide bonds in mucoproteins. It also promotes the detoxification of an intermediate paracetamol metabolite which is used in the management of paracetamol overdosage.

Drug Interactions ::

Drug stability and safety of acetylcysteine when mixed with other drugs in a nebulizer have not been established.