The Brand Name PROXECEF Has Generic Salt :: CEFDITOREN
PROXECEF Is From Company Ajanta Ph. Priced :: Rs. 222
PROXECEF have CEFDITOREN is comes under Sub class Cephalosporins of Main Class Anti Infectives
Main Medicine Class:: Anti Infectives Sub Medicine Class :: Cephalosporins
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Indications for Drugs ::
Pharyngitis, Community-acquired pneumonia, Susceptible infections, Tonsillitis, Soft tissue infections, Respiratory tract infections, Acute Exacerbations of Chronic bronchitis
Drug Dose ::
Adult: PO Community-acquired pneumonia; Acute bacterial exacerbation of chronic bronchitis 400 mg twice daily. Treatment duration: 10-14 days. Pharyngitis; Tonsilitis; Uncomplicated skin and skin structure infections 200 mg twice daily for 10 days. Renal impairment: CrCl (ml/min) 30-49 Maximum: 200 mg bid <30 Maximum: 200 mg once daily Contraindication ::
Hypersensitivity to Cefditoren, other cephalosporins; or milk proteins. Carnitine deficiency.
Drug Precautions ::
Pregnancy and lactation. Patients with penicillin allergy. Avoid prolonged use as pivalate-containing compounds may cause carnitine deficiency over time; greater risk of carnitine deficiency in patients with renal impairment or decreased muscle mass. May decrease prothrombin activity especially in patients with renal or hepatic impairment, poor nutritional status, prolonged antibiotic treatment or patients previously stabilised on anticoagulant therapy. Long term use may result in development of drug-resistant bacteria, or superinfection including Clostridium difficile-associated diarrhoea and pseudomembranous colitis.
Drug Side Effects ::
Diarrhoea, nausea, headache, abdominal pain, vaginal moniliasis, dyspepsia, vomiting, haematuria, increased urine white blood cells, decreased haematocrit, increased glucose, interstitial pneumonia, acute eosinophilic pneumonia, acute renal failure, arthralgia, thrombocytopenia, erythema multiforme. Pseudomembranous colitis symptoms may occur during or after antibiotic treatment. Potentially Fatal: Hypersensitivity, anaphylaxis, Stevens-Johnson syndrome, toxic epidermal necrolysis.
Pregnancy category ::
Drug Mode of Action ::
Cefditoren is a third generation cephalosporin used for treatment of susceptible infections caused by gram-positive and gram-negative bacteria. It inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs).
Drug Interactions ::
Reduced oral bioavailability when coadministered with antacids or H2-receptor antagonists. Probenecid may increase plasma concentration and prolong half-life of Cefditoren. May enhance anticoagulant effect of vitamin K antagonists (e.g. warfarin).