The Brand Name PURINOL Has Generic Salt :: Allopurinol
PURINOL Is From Company HANBURYS Priced :: Rs. 216.00/446.00
PURINOL have Allopurinol is comes under Sub class Anti Gout Drugs of Main Class Musculoskeletal Disorders , Pain
Main Medicine Class:: Musculoskeletal Disorders , Pain Sub Medicine Class :: Anti Gout Drugs
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Indications for Drugs ::
Hyperuricaemia, Uric acid nephropathy, Cancer therapy-induced hyperuricaemia, Gout, Recurrent renal stones
Drug Dose ::
Adult: PO Gout; Hyperuricaemia Initial: 100 mg/day, may adjust dose according to response. Max: 800 mg/day. Prevention of hyperuricaemia associated w/ chemotherapy treatment or enzyme disorders 600-800 mg/day, starting 2-3 days before cancer treatment. Renal impairment: Haemodialysis: Administer dose after session or administer 50% supplemental dose. CrCl (ml/min) 10-20 200 mg daily. <3 100 mg daily at extended intervals. 3-10 100 mg daily. Hepatic impairment: Dose reduction may be needed. Monitor liver function regularly. Contraindication ::
Hypersensitivity; acute attack of gout.
Drug Precautions ::
Ensure adequate fluid intake. Prophylactically with an anti-inflammatory or colchicine for at least 1 mth. Withdraw immediately when sensitivity (skin rash, etc) appears. Pregnancy, lactation. Hepatic and renal impairment.
Drug Side Effects ::
Rash; alopoecia; GI disorders, taste disturbances, nausea, vomiting, abdominal pain, diarrhoea; paraesthesia, peripheral neuropathy, vertigo, headache, hepatic necrosis, drowsiness, neuritis, arthralgia; hypertension. Potentially Fatal: Stevens-Jonhson and/or Lyell’s Syndrome (urticaria, fever, lymphadenopathy, arthralgia). Occasionally, thrombocytopaenia, agranulocytosis and aplastic anaemia.
Pregnancy category ::
Drug Mode of Action ::
Allopurinol is an inhibitor of the enzyme xanthine oxidase which converts hypoxanthine to xanthine then uric acid. The reduced production of uric acid relieves all symptoms associated with hyperuricaemia and gout. Inhibition of xanthine oxidase leads to accumulation of its substrates hypoxanthine and xanthine but since their renal clearance is more than 10 times that of uric acid, there is no risk of nephrolithiasis.
Drug Interactions ::
May inhibit the metabolism of mercaptopurine and azathioprine; reduce dose of mercaptopurine and azathioprine when given w/ allopurinol. May increase effect of warfarin and other coumarin anticoagulants. Increased excretion of the oxipurinol (metabolite) w/ salicylates or uricosuric agents. Increased toxicity w/ thiazide diuretics, some antibacterials, other antineoplastics, ciclosporin, some sulfonylurea antidiabetics, theophylline and vidarabine.