The Brand Name PURON Has Generic Salt :: DEXKetoprofen 

PURON  Is From Company Zuventus Priced :: Rs. 75

PURON have DEXKetoprofen is comes under Sub class #N/A of  Main Class #N/A

Main Medicine Class:: #N/A  Sub Medicine Class :: #N/A 

Indications for Drugs ::

Pain, Dysmenorrhea, Rheumatic disorders

Drug Dose ::

Adult: PO Rheumatic disorders 100-200 mg/day in 2-4 divided doses. Max: 300 mg/day in divided doses. Pain and inflammation 25-50 mg 6-8 hrly. Max: 300 mg/day. IM Pain and inflammation associated w/ musculoskeletal and joint disorders; Pain following orthopaedic surgery 50-100 mg by deep inj into the gluteal muscle 4 hrly. Max: 200 mg/24 hr for up to 3 days.

Contraindication ::

Dexketoprofen tablets are not recommended to use in patients who are: – Allergic to this product or any of its components, aspirin or other non-steroidal anti-inflammatory medicines. – Have suffered attacks of asthma, bronchospasm, acute rhinitis, nasal polyps, urticaria, angioedema (swollen face, eyes, lips, or tongue, or difficulty in breathing), after taking aspirin or other non-steroidal anti-inflammatory medicines. – Have or have previously suffered from a peptic ulcer or chronic gastro-intestinal disorders. – Have had previously gastro-intestinal haemorrhage (bleeding). – Have suffered from bronchial asthma. – Have severe heart failure, moderate to severe renal dysfunction or severely impaired hepatic function. – Have a bleeding disorder, a blood clotting disorder or taking an anticoagulant. – Pregnant or breast-feeding.

Drug Precautions ::

The medicine should be used with caution in conditions mentioned below: – Allergic to any other medicines. – Kidney disease, liver disease, heart disease or fluid retention conditions. – Blood disorder, systemic lupus erythematosus or mixed connective tissue disease.

Drug Side Effects ::

As with all medicines, Dexketoprofen may cause some unwanted effects in some patients. These are described below and are characteristic of non steroidal anti-inflammatory drugs: – Common (1 – 10%): nausea, vomiting, diarrhoea, stomach pain or heartburn. – Uncommon (0.1 – 1%): sleep disorders, nervousness, headache, dizziness,vertigo, palpitations, constipation, dry mouth, flatulence, skin rash, fatigue, hot flushes, shivering, general malaise. – Rare (0.01-0.1%): stomach ulceration, gastric haemorrhage or perforation, pins and needles, high blood pressure, water retention, slowed breathing rate, increased hepatic enzymes, increased sweating. – Very rare / isolated cases (<0.01%): blurred vision, ringing in the ear, low blood pressure, haematological reactions, hepatic or renal damage, dermatological and photosensitivity reactions, bronchospasm or anaphylaxis. - In patients with systemic lupus erythematosus or mixed connective tissue disease, anti-inflammatory medicines may rarely cause isolated cases of fever, headache and rigidity of the nape (back of the neck). Pregnancy category ::

4

Drug Mode of Action ::  

Dexketoprofen exhibits anti-inflammatory, analgesic and antipyretic properties. It potently inhibits the enzyme cyclooxygenase resulting in prostaglandin synthesis inhibition.

Drug Interactions ::

Increased risk of GI ulcers & bleeding (synergistic effect) w/ other NSAIDs. Increased risk of haemorrhagic effect of oral anticoagulants. Increased risk of haemorrhage w/ heparin. Increased blood lithium levels, which may reach toxic values, w/ lithium. Increased haematological toxicity of methotrexate at high dose of ?15 mg/wk. Increased toxic effects of hydantoins & sulphonamides. Increase risk of bleeding & damage of GI mucosal w/ anticoagulant. Increase hypoglycemic effect of sulfonylurea agents.