The Brand Name RA-QUIN Has Generic Salt :: HYDROXYCHLOROQUINE 

RA-QUIN  Is From Company Ranbaxy Priced :: Rs. 66.25

RA-QUIN have HYDROXYCHLOROQUINE is comes under Sub class #N/A of  Main Class #N/A

Main Medicine Class:: #N/A  Sub Medicine Class :: #N/A 

Indications for Drugs ::

i) Acute and chronic rheumatoid arthritis, ii) Systemic Lupus Erythematosus (SLE), iii) Malaria

Drug Dose ::

Hydroxychloroquine Sulphate tablets are for oral administration and are taken with food to avoid stomach upset. i) Acute and chronic rheumatoid arthritis: 400 to 600 mg daily. When good response is obtained (usually 4 to 8 weeks), dose can be reduced to 50%. ii) Systemic Lupus Erythematosus (SLE): 400 mg once or twice daily for several weeks or months depending on response of the patients. Maintenance dose is 200 to 400 mg daily. iii) Malaria: In adults, an initial dose of 800 mg followed by 400 mg in 6-8 hours and 400 mg on each of two consecutive days. For children a total dose representing 25 mg/kg is administered in 3 days as follows. First dose: 10 mg base/kg (but not exceeding a single dose of 620 mg base). Second dose: 5 mg base/kg (but not exceeding a single dose of 310 mg base) 6 hours after first dose. Third dose: 5 mg base/kg 18 hours after second dose. Fourth dose: 5 mg base/kg 24 hours after third dose. * Hydroxychloroquine Sulphate BP 200 mg equivalent to 155 mg of base.

Contraindication ::

The presence of retinal or visual field changes attributable to any 4-aminoquinoline compound, patients with known hypersensitivity to 4-aminoquinoline compounds, long term therapy in children.

Drug Precautions ::

Children are especially sensitive to the 4-aminoquinoline compounds. Patients should be strongly warned to keep these drugs out of the reach of children. Opthalmologic examination requires in every 12 months.

Drug Side Effects ::

Generally Hydroxychloroquine Sulphate is well tolerated. However, few side effects like nausea, vomiting, stomach upset, loss of appetite, diarrhea, tiredness, weakness or headache and visual problem may occur the first several days.

Pregnancy category ::

3

Drug Mode of Action ::  

Hydroxychloroquine is a 4-aminoquinoline antimalarial with actions similar to those of chloroquine but is mainly used in the treatment of SLE and rheumatoid arthritis. It interferes with digestive vacuole function within susceptible malarial parasites by increasing pH and interrupting with lysosomal degradation of Hb thus impeding normal cell function of sensitive parasites.

Drug Interactions ::

Cimetidine may increase serum levels of hydroxychloroquine. Its absorption may be decreased by kaolin or Mg trisilicate. Avoid digoxin and alcohol. Increased risk of ventricular arrhythmias when used with halofantrine. Concurrent use with mefloquine may increase the risk of convulsions.