Details About Generic Salt ::  Saquinavir 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

13N. ANTI-RETROVIRALS (DRUGS FOR HIV) in 13. ANTI-INFECTIVES
SAQUINAVIR
PROTEASE INHIBITOR | ANTI-RETROVIRAL
PK: A: Poor D: 700 L(Vd) M: Hepatic E: Feces (81%-88%), urine (1%-3%) within 5 days

Indications & Dose: TREATMENT OF HIV INFECT PO Adult 1g saquinavir with ritonavir 100mg BID

Contra: Hypersensitivity, congenital/acquired QT prolongation, refractory hypokalemia/hypomagnesemia, severe hepatic impairment, patients at high risk of complete AV block, Concurrent use of antiarrhythmics, astemizole, cisapride, terfenadine, ergot derivatives, midazolam, pimozide, rifampin & triazolam

Precautions: Mild-to-moderate hepatic impairment, hemophilia A/B, DM

ADR: Serious: Acute myeloid leukemia, hemolytic anemia, pancreatitis, nephrolithiasis, polyarthritis, metabolic abnormalities, rhabdomyolysis, myalgia, lipodystrophy, peripheral neuropathy, SJS, thrombocytopenia, lowered Hb, platelet, lymphocyte & WBC count, Others: intestinal obstruction, seizures, alopecia, anorexia, increased appetite, constipation, dizziness, dyspepsia, dyspnoea, headache, decreased libido, paraesthesia, pruritus, rash, sleep disturbances & taste disorders, muscle spasm, malaise, asthenia, GI disorders, fatigue, elevated creatine phosphokinase, increased blood amylase, bilirubin & creatinine

DDI: Serious Midazolam bioavailability increased, Nevirapine/Efavirenz increases adverse effects, Fluconazole/Clarithromycin/H2RA/PPIs increases drug levels, Digoxin/Ciclosporin/Quinidine/Sildenafil level increased, Methadone level reduced, Statins levels increased, Rifampicin/Loperamide reduces drug bioavailability, Dexamethasone reduces drug level

Diet: After food (2h)

Monitor: ECG, Se potassium & magnesium levels, triglycerides & cholesterol, viral load, CD4 count, glucose

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