Article Contents ::
Details About Generic Salt :: Teniposide
Main Medicine Class:: #N/A Sub Medicine Class :: #N/A
| 18A. ANTI-NEOPLASTIC AGENTS in 18. ANTI-NEOPLASTIC AGENTS |
| TENIPOSIDE |
| PODOPHYLLOTOXIN DERIVATIVE | ANTI-NEOPLASTIC |
| PK: D: Low (99.4% protein bound) M: Hepatic E: urine & feces |
|
Indications & Dose: ACUTE LYMPHOBLASTIC LEUKEMIA Consolidation therapy IV Child 165mg/m2 on 1, 4, 8, &11 days; Dilute (0.1, 0.2, 0.4, 1mg/mL)& slow inf>30-60min |
| Contra: Hypersensitivity
Precautions: Hepatic & renal impairment, Avoid live vaccination, Hypotension ADR: Serious: Myelosuppression, Infection, Bleeding, Diarrhea, Nausea, Vomiting, Mucositis, Hypotension, Tachycardia, Secondary AML, Others: Rash, Alopecia, Anemia, Neurotoxicity, Metabolic abnormalities DDI: Serious Vaccines (Live) adverse/toxic effects are enhanced, CYP3A4 Inhibitors May reach toxic levels, CYP3A4 Inducers Reduced efficacy, Zidovudine/Clozapine Severe myelosuppression, Vaccines (Live & inactivated) Therapeutic effect is diminished by teniposide Monitor: BP; CBC, RFT, LFT |
