Indications & Dose: DELAYED PUBERTY IM Adult 50-200mg q2-4wk 4-6 month (enanthate) | INOPERABLE METASTATIC BREAST CANCER IM Adult 200-400mg (as enanthate) q2-4wk in females | MALE HYPOGONADISM BCL Adult SR: Apply 30mg BID | IM Adult 50-400mg q2-4wk (as cipionate/enantate), 50mg 2-3 times weekly (as propionate), 1g q10-14wk (as undecylate) | SC Adult Implant: 100-600mg plasma concentrations usually maintained within the physiological range for 4-5 months with 600mg dose | TD Adult Patches: 2.5-7.5mg/day

Precautions: CVD, renal/hepatic impairment, epilepsy, migraine, DM, conditions that may be aggravated by fluid retention/ edema, skeletal metastases, elderly, pediatrics

ADR: Serious: DVT, edema, HTN, vasodilation, contact dermatitis, hyperlipidemia, GI bleeding, prostatic carcinoma/hyperplasia, testicular atrophy, phlebitis, cholestatic hepatitis/jaundice, hepatic necrosis, hepatocellular neoplasms, leukopenia, polycythemia, suppression of clotting factors, bleeding, anaphylactoid reactions, increased SeCr, enlargement of clitoris/penis, seizure, hypercalcemia, hyperkalemia/hypokalemia, leukopenia, Others: bladder irritability, impotence, oligospermia, impaired LFTs, increased libido, amnesia, anxiety, depression, dizziness, headache, hostility, insomnia, malaise, increased appetite, GI irritation, nausea, taste disorder, vomiting, weight gain, gum pain/tenderness, taste perversion, sleep apnea, acne, alopecia, dry skin, folliculitis, hair discoloration, hirsutism, rash, seborrhea, breast pain/soreness, gynecomastia, hot flashes, hypernatremia, libido, amenorrhea, anemia, polycythemia, hyperkinesia, dyspnea, transdermal

DDI: Serious Antidiabetics efficacy is enhanced, Anticoagulants efficacy is increased, Finasteride/Dutasteride increases drug levels, Levothyroxine/Ciclosporin levels are increased

Monitor: LFTs, cholesterol, Hb, haematocrit, radiologic examination of wrist & hand, serum calcium & glucose, BMD, prostate exam