Indications & Dose: ANAEROBIC BACTERIAL INFECT PO Adult Initially 2g/day, followed by 1g/day on subsequent days or 500mg BID 5-6 days | IV Adult Initially 800mg/400mL at a rate of 10mL/min, followed by 800mg/day or 400mg BID | BACTERIAL VAGINOSIS PO Adult 2g single dose or 2g OD 2 successive days or 1g/day 5 days | GIARDIASIS PO Adult 2g/day single dose Child 50-75mg/kg single dose | HEPATIC AMOEBIASIS PO Adult 1.5-2g/day single dose 3-6 days Child 50-60mg/kg/day 3-5 daysFollowed by a luminal amoebicide | INTESTINAL AMOEBIASIS PO Adult 2g/day single dose 2-3 days Child 50-60mg/kg/day 3-5 daysFollowed by a luminal amoebicide | PEPTIC ULCER Combination therapy PO Adult 500mg BID 7 days with clarithromycin & omeprazole | POSTOPERATIVE ANAEROBIC BACTERIAL INFECT PO Adult 2g as given 12h before surgery | IV Adult Inf: 1.6g before surgery | TRICHOMONIASIS PO Adult 2g/day single dose Child 50-75mg/kg single dose | ULCERATIVE GINGIVITIS PO Adult 2g/day single dose

Precautions: CNS diseases, avoid alcohol

ADR: Serious: peripheral neuropathy, thrombocytopenia, Others: moderate leucopenia, nausea, unpleasant metallic taste, vomiting, diarrhea, constipation, glossitis, stomatitis, weakness, dizziness, drowsiness, insomnia, darkening of urine

DDI: Serious Rifampicin increases drug clearance, Coumarins increases risk of hemorrhage, Alcohol leads to disulfiram-like reaction, Cimetidine reduces drug metabolism

Diet: After food