Details About Overdose or Poisoning Generic Salt :: Cyproheptadine
Drug Pharmacology ::
I. Pharmacology. Cyproheptadineis a first-generation, histamine-1 blocker with nonspecific serotonin(5-HT) antagonism. The administration of cyproheptadine to patientswith serotonin syndrome appears to antagonize excessive stimulation of5-HT1A and 5-HT2 receptors, resulting in improvements in clinicalsymptoms (based on anecdotal case reports).
Drug Indications ::
Indications. Cyproheptadine may be beneficial in alleviating mild to moderate symptoms in cases of suspected serotonin syndrome (see Serotonin syndrome).
Drug Contra-Indications ::
Known hypersensitivity to cyproheptadine.
Stenosing peptic ulcer.
Symptomatic prostatic hypertrophy.
E. Bladder neck obstruction.
F. Pyloroduodenal obstruction.
Drug Adverse Effects ::
IV. Adverse effects
Transient mydriasis and urinary retention may result from anticholinergic properties.
Use in pregnancy. FDA category B (see Table III–1). Unlikely to cause harm with short-term therapy.
Drug Lab Interactions ::
Drug or laboratory interactions. Additive anticholinergic effects when given with other antimuscarinic drugs.
Drug Dose Management ::
Dosage and method of administration (adults and children)
Oral. Theinitial dose is 4–8 mg orally and can be repeated every 1–4 hours asneeded until symptoms resolve or a maximum daily dose of 32 mg isreached (children: 0.25 mg/kg/day divided every 6 hours with a maximumof 12 mg/day).
Drug Chemical Formulations ::
Oral. Cyproheptadine hydrochloride (Periactin, others), 4-mg tablets, 2 mg/5 mL syrup.
The suggested minimum stocking level to treat a 70-kg adult for the first 24 hours is one bottle (4 mg, 100 tablets).