Article Contents ::
Details About Generic Salt :: Metformin
Main Medicine Class:: Endocrine,Steroid Hormones , Metabolic System Sub Medicine Class :: Insulin , Anti Diabetic drugs
| 8D. INSULIN & ANTI-DIABETIC DRUGS in 8. ENDOCRINE/STEROID HORMONES & METABOLIC SYSTEM |
| METFORMIN |
| BIGUANIDE | ANTI-DIABETIC |
| PK: A: Slow D: 654 ± 358(Vd) E: Urine(90%) |
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Indications & Dose: POLYCYSTIC OVARIAN SYNDROME PO Adult Initially 500mg OD morning 1 wk, then 500mg BID max 1.5–1.7g/day in 2–3 divided doses | TYPE 2 DIABETES MELLITUS PO Adult Initially 500mg OD for at least 1 wk, then 500mg BID 1wk, then 500mg TID, max 2g/day in divided doses, Modified-release preparation: Initially 500mg OD, increase by 500mg, at intervals of at least 1 wk max 2g/day with evening meal Child >10 yr: Initially 500mg OD for at least 1 wk, then 500mg BID 1wk, then 500mg TID, max 2g/day in divided doses |
| Contra: Hypersensitivity, acute MI, septicemia, acute/chronic metabolic acidosis
Precautions: Elderly, renal/hepatic impairment ADR: Serious: Hypoglycemia, lactic acidosis, hepatitis, rash, Others: Chills, dizziness, abdominal discomfort, constipation, palpitation, nausea, vomiting, pruritus, headache, dyspepsia DDI: Serious Gatifloxacin causes abnormal glucose homoeostasis, Fluticasone/Budesonide causes hyperglycemia, Cimetidine causes lactic acidosis, Orlistat increases drug effects, cefalexin increases drug level, Iodinated contrast media may cause renal failure, which could result in lactic acidosis, Disopyramide occasionally causes hypoglycaemia Diet: With food Monitor: Urine for glucose & ketones, blood glucose, HbA1c & renal function |