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Gliclazide

Details About Generic Salt ::  Gliclazide 

Main Medicine Class:: Endocrine,Steroid Hormones , Metabolic System   Sub Medicine Class ::  Insulin , Anti Diabetic drugs

8D. INSULIN & ANTI-DIABETIC DRUGS in 8. ENDOCRINE/STEROID HORMONES & METABOLIC SYSTEM
GLICLAZIDE
SULFONYLUREA | ANTI-DIABETIC
PK: A: Rapid M: Hepatic E: Urine(60% to 70%) & feces (10% to 20%)

Indications & Dose: TYPE 2 DIABETES MELLITUS PO Adult IR tablet: Initially 80-160mg/day, doses >160mg/day should be given in 2 equal divided doses, max 320mg/day, SR tablet: 30-120mg/day

Contra: Hypersensitivity, type 1 DM, DKA

Precautions: Elderly, hepatic/renal impairment

ADR: Serious: Hypoglycemia, jaundice, thrombocytopenia, hepatitis, Others: dizziness, headache, anorexia, constipation, diarrhea, epigastric fullness, nausea, paresthesia, myalgia

DDI: Serious Rifampicin reduces drug effects, Fluconazole/Disopyramide/Miconazole results in hypoglycemia

Diet: With food

Monitor: Blood glucose & Hb A1c

Miglitol

Details About Generic Salt ::  Miglitol 

Main Medicine Class:: Endocrine,Steroid Hormones , Metabolic System   Sub Medicine Class ::  Insulin , Anti Diabetic drugs

8D. INSULIN & ANTI-DIABETIC DRUGS in 8. ENDOCRINE/STEROID HORMONES & METABOLIC SYSTEM
MIGLITOL
ALPHA-GLUCOSIDASE INHIBITOR | ANTI-DIABETIC
PK: A: Variable D: 0.18 L/kg (Vd) E: Urine

Indications & Dose: TYPE 2 DIABETES MELLITUS PO Adult Initially 25mg TID, increase to 50mg TID after 4-8 wk max 100mg TID

Contra: Hypersensitivity, DKA, colonic ulceration, partial intestinal obstruction, type 1 DM, chronic intestinal disorder, severe renal impairment

Precautions: Mild-to-moderate renal impairment

ADR: Others: Abdominal pain, diarrhea, flatulence, rash, skin reactions, edema

DDI: Serious Ranitidine AUC decreased, Propranolol bioavailability reduced, Metformin/Glibenclamide/Rosiglitazone plasma levels decreases

Diet: With food

Monitor: Blood glucose tests, measurement of glycosylated hemoglobin

Pioglitazone , Metformin

Details About Generic Salt ::  Pioglitazone , Metformin 

Main Medicine Class:: Endocrine,Steroid Hormones , Metabolic System   Sub Medicine Class ::  Insulin , Anti Diabetic drugs

8D. INSULIN & ANTI-DIABETIC DRUGS in 8. ENDOCRINE/STEROID HORMONES & METABOLIC SYSTEM
PIOGLITAZONE + METFORMIN
THIAZOLIDINEDIONE, BIGUANIDE | ANTI-DIABETIC

Indications & Dose: TYPE 2 DIABETES MELLITUS Chronic PO Adult Initially pioglitazone 15mg/ metformin 500mg or pioglitazone 15mg/metformin 850mg OD/BID, max pioglitazone 45mg/metformin 2.55g/day. Titrate dose based upon response

Contra: renal impairment, hepatic impairment

Acarbose

Details About Generic Salt ::  Acarbose 

Main Medicine Class:: Endocrine,Steroid Hormones , Metabolic System   Sub Medicine Class ::  Insulin , Anti Diabetic drugs

8D. INSULIN & ANTI-DIABETIC DRUGS in 8. ENDOCRINE/STEROID HORMONES & METABOLIC SYSTEM
ACARBOSE
A-GLUCOSIDASE INHIBITOR | ANTI-DIABETIC
PK: A: Poor D: 0.32 L/kg (IV) M: GIT E: Urine % Feces

Indications & Dose: TYPE 2 DIABETES MELLITUS PO Adult Initially 25mg/day, may increase to TID based on tolerance, MD 50-100mg TID, may adjust dose q4-8wk intervals based on 1h PPG levels & tolerance max 50mg TID (<60 kg) or 100mg TID (>60 kg)

Contra: Hypersensitivity, DKA, cirrhosis, IBD, colonic ulceration, chronic intestinal diseases, renal impairment, type 1 DM, children & adolescent

Precautions: Increased hypoglycemic effects

ADR: Serious: edema, erythema, exanthema, hepatitis, ileus/subileus, jaundice, pneumatosis cystoides intestinalis, thrombocytopenia, urticaria, Others: rash, flatulence, increased transaminases, diarrhea, abdominal pain

DDI: Serious Colestyramine increases drug efficacy, Neomycin increases drug efficacy & GI adverse effects

Diet: With food (first bite of meal)

Monitor: PPG, HbA1c,LFT, SeCr

Pioglitazone , Glimepiride

Details About Generic Salt ::  Pioglitazone , Glimepiride 

Main Medicine Class:: Endocrine,Steroid Hormones , Metabolic System   Sub Medicine Class ::  Insulin , Anti Diabetic drugs

8D. INSULIN & ANTI-DIABETIC DRUGS in 8. ENDOCRINE/STEROID HORMONES & METABOLIC SYSTEM
PIOGLITAZONE + GLIMEPIRIDE
THIAZOLIDINEDIONE & SULFONYLUREA | ANTI-DIABETIC

Indications & Dose: TYPE 2 DIABETES MELLITUS Chronic PO Adult Inadequately controlled on glimepiride: Pioglitazone 30mg/Glimepiride 2mg or 30mg/4mg OD, Inadequately controlled on pioglitazone: Pioglitazone 30mg/Glimepiride 2mg OD, Patients with systolic dysfunction (NYHA class I & II): 30mg/2mg or 30mg/4mg OD

Contra: renal disease, hepatic impairment

Voglibose

Details About Generic Salt ::  Voglibose 

Main Medicine Class:: Endocrine,Steroid Hormones , Metabolic System   Sub Medicine Class ::  Insulin , Anti Diabetic drugs

8D. INSULIN & ANTI-DIABETIC DRUGS in 8. ENDOCRINE/STEROID HORMONES & METABOLIC SYSTEM
VOGLIBOSE
ALPHA-GLUCOSIDASE INHIBITOR | ANTI-DIABETIC
PK: M: Intestine E: Urine & feces

Indications & Dose: DIABETES MELLITUS PO Adult 200-300µg TID

Contra: Hypersensitivity, IBD with ulceration, chronic intestinal diseases, hernia, hepatic impairment

ADR: Serious: hepatotoxicity, skin reactions, Others: GI disturbances, abdominal distension, diarrhea

DDI: Serious Gatifloxacin severe hypoglycemia

Diet: Before food