Acute Myocardial Infarction (AMI) Causes PATHOPHYSIOLOGY and Etiology

AcuteMitral Stenosis Causes Symptoms of Mitral Stenosis Etiology of Mitral Stenosis Treatment of Mitral Stenosis. Read more ... » Myocardial Infarction AMI CausesMitral Stenosis Causes Symptoms of Mitral Stenosis Etiology of Mitral Stenosis Treatment of Mitral Stenosis. Read more ... » PATHOPHYSIOLOGY  Atherosclerosis and Etiology

CausesMitral Stenosis Causes Symptoms of Mitral Stenosis Etiology of Mitral Stenosis Treatment of Mitral Stenosis. Read more ... » AcuteMitral Stenosis Causes Symptoms of Mitral Stenosis Etiology of Mitral Stenosis Treatment of Mitral Stenosis. Read more ... » Myocardial Infarction Etiology:

  • Proven risk factors for MI are tobacco use,
  • high blood pressure, male sex, advanced age, obesity, physical inactivity
  • diabetes mellitus, abnormal cholesterol levels,
  • high blood pressure, male sex, advanced age, obesity, physical inactivity
  • AMI may be associated with ST elevation or ST de­pression in the ECG.
  • AMI With ST elevation is called STEMI (ST segment elevation MI) and AMI without ST segment elevation is called NSTEMI (Non ST seg­i]1ent elevation MI).
  • In NSTEMI cardiacMitral Stenosis Causes Symptoms of Mitral Stenosis Etiology of Mitral Stenosis Treatment of Mitral Stenosis. Read more ... » markers like troponins are normal (not elevated).
  • In TEMI~ardc markers like  troponins are elevated.
  • Q waves do not evolve in NSTEMI but Q waves are
  • seen to evolve in STEMI. ~
  • Mortalit is 30%. 25% die in 1st year after AMI

PATHOPHYSIOLOGY CausesMitral Stenosis Causes Symptoms of Mitral Stenosis Etiology of Mitral Stenosis Treatment of Mitral Stenosis. Read more ... » of AcuteMitral Stenosis Causes Symptoms of Mitral Stenosis Etiology of Mitral Stenosis Treatment of Mitral Stenosis. Read more ... » Myocardial Infarction

I. Atherosclerosis

  • Coronary arteries are narrowed by athero­sclerosis.
  • Abrupt closure can occur by throm­botic occlusion.
  • Very gradual narrowing leads to development of collaterals and therefore lesser incidence of MI.

 

Factors which precipitate thrombotic occlusion of coronary vessels are:

   

  • Vascular injury (damage to endothelium of coro­naries)
  • Vascular injury is precipitated by cigarette smoking, hypertension and hyperlipidemia.
  • Fissuring of atherosclerotic plaque
  • Rupture of atherosclerotic plaque
  • Ulceration

AcuteMitral Stenosis Causes Symptoms of Mitral Stenosis Etiology of Mitral Stenosis Treatment of Mitral Stenosis. Read more ... » Myocardial Infarction CausesMitral Stenosis Causes Symptoms of Mitral Stenosis Etiology of Mitral Stenosis Treatment of Mitral Stenosis. Read more ... » Thrombogenesis

  • Atherosclerotic plaque with rich lipid core and thin @:>rous cap are very p..!:one to rupture.
  • Iatelets are activated by: ADP
  • Collagen Epinephrine  Serotonin.
  • There is release of thromboxane A2

 

Thtrhromboxane A2 is a potent

II. Total Coronary occlusion resulting in Acute MI occurs due to :

  • Presence of multiple risk factors
  • Hypercoagulability
  • Collagen vascular disease
  • Cocaine abuse
  • Intracardiac thrombi or masses leading to coronary embolization.

III. Other causesMitral Stenosis Causes Symptoms of Mitral Stenosis Etiology of Mitral Stenosis Treatment of Mitral Stenosis. Read more ... » of Coronary occlusion are less important e.g. :

  • Coronary embolism
  • Congenital abnormalities
  • Coronary spasm
  • Systemic and inflammatory disease .