Details About Generic Salt ::  Alitreti

Main Medicine Class:: Topical,endogenous retinoid   

(al-ih-TREH-tih-NO-in)

Panretin

Class: Topical/endogenous retinoid

Drugs Class ::

 Action Regulates genes that control cellular differentiation and proliferation of healthy and neoplastic cells by binding to and activating intracellular retinoid receptor subtypes; in vitro inhibition of growth of Kaposi’s sarcoma (KS) cells.

Indications for Drugs ::

 Indications Treatment of cutaneous lesions in patients with AIDS-related KS.

Drug Dose ::

 Route/Dosage

ADULTS: Topical Initially apply bid to cutaneous lesions, gradually increasing to tid or bid, according to individual-lesion tolerance. Apply sufficient gel to generously coat lesion.

Contraindication ::

 Contraindications Standard considerations.

Drug Precautions ::

 Precautions

Pregnancy: Category D. Lactation: Unknown. Children: Safety and efficacy not established. Elderly Patients: Safety and efficacy not established. Photosensitivity: Although not reported, in vitro data indicate a weak potential.

Drug Side Effects ::

 Adverse Reactions

DERM: Rash; erythema; scaling; irritation; redness; dermatitis; pain; burning; pruritus; itching; exfoliative dermatitis; flaking; peeling; desquamation; excoriation; cracking skin; scabbing; crusting; drainage; eschar; fissure; oozing; paresthesia; stinging; tingling; edema; swelling; inflammation.

Drug Mode of Action ::  

 Action Regulates genes that control cellular differentiation and proliferation of healthy and neoplastic cells by binding to and activating intracellular retinoid receptor subtypes; in vitro inhibition of growth of Kaposi’s sarcoma (KS) cells.

Drug Interactions ::

 Interactions

N, N-diethyl-m-toluamide (DEET): DEET toxicity may be increased.

Drug Assesment ::

 Assessment/Interventions

• Obtain patient history, including drug history and any known allergies.
• Monitor for signs of hypersensitivity and adverse reactions (eg, rash, pain, pruritus, exfoliative dermatitis, paresthesia, edema, swelling), which usually occur at the site of application.
• Discontinue use if signs of hypersensitivity are present and notify primary health care provider.
• Do not administer if systemic or other anti-KS therapy if required.
• Monitor for potential dermal toxicity, which usually begins as mild erythema and increases with continued application leading to intense erythema, edema, and vesiculation.
• Assess the patient for symptoms of systemic signs and symptoms of KS.
• If < 10 new KS lesions in the prior month or symptoms of lymphedema, pulmonary KS, or visceral involvement are present, do not administer and report findings to primary care provider.

Drug Storage/Management ::

 Administration/Storage

• Store tubes at room temperature (25°C; 77°F) with excursions permitted to 15° to 30°C (59° to 86°F)).
• Apply as directed with sufficient gel to cover the lesions. Allow to dry 3 to 5 min before covering with clothing.
• Do not cover with occlusive dressings.
• Do not apply to surrounding skin, as unaffected skin may become irritated.
• Do not apply on or near mucosal membranes

Drug Notes ::

 Patient/Family Education

• Teach patient that alitretinoin is for topical use only, and give instructions for correct application.
• Advise patient that the response to treatment is not immediate, but may require from ³ 2 to 14 wks for response.
• Discontinue medicine immediately if signs of hypersensitivity are present and notify primary health care provider.
• Warn patient not to use alitretinoin concurrently with insect repellent products that contain DEET, as the combination could lead to an increased risk of DEET toxicity.
• Advise patient of the photosensitivity potential, and to avoid exposure of treated areas to direct sunlight.
• Advise patient to avoid exposure of treated areas to sunlight or sunlamp.
• Warn women with childbearing potential to avoid becoming pregnant, and apprise them of the potential hazard to the fetus.
• Nursing mothers should discontinue nursing prior to using the drug.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.