Details About Generic Salt ::  Atovaquo

Main Medicine Class:: Anti-infective,antiprotozoal   

Class: Anti-infective/antiprotozoal


Drugs Class ::

 Action Inhibits mitochondrial electron transport in metabolic enzymes of microorganisms. This may cause inhibition of nucleic acid and adenosine triphosphate synthesis.

Indications for Drugs ::

 Indications Treatment of mild-to-moderate Pneumocystis carinii pneumonia (PCP) in patients who are intolerant of trimethoprim-sulfamethoxazole and acute oral treatment of mild-to-moderate PCP in patients who are intolerant to trimethoprim-sulfamethoxazole (TMP-SMZ).

Drug Dose ::


Prevention of PCP

ADULTS AND CHILDREN 13 TO 16 YR: PO 1500 mg once daily with a meal.

Treatment of mild-to-moderate PCP

ADULTS AND CHILDREN 13 TO 16 YR: PO 750 mg administered with food twice daily for 21 days (total daily dose 1500 mg).

Contraindication ::

 Contraindications Standard considerations.

Drug Precautions ::


Pregnancy: Category C. Lactation: Undetermined. Children: Safety and efficacy not established. Hepatic function impairment: Use caution and closely monitor administration. Elderly: Atovaquone has not been systematically evaluated in patients > 65 yr. Severe PCP: Treatment of severe episodes of PCP has not been evaluated. Efficacy in patients not responding to trimethoprim-sulfamethoxazole has not been established. Atovaquone has not been evaluated for prophylaxis of PCP.


Drug Side Effects ::

 Adverse Reactions

CNS: Headache; insomnia; dizziness; anxiety. DERM: Rash; pruritus. EENT: Sinusitis; rhinitis; altered taste. GI: Nausea; diarrhea; vomiting; abdominal pain; constipation; oral monilia; anorexia; dyspepsia. GU: Elevated creatinine; elevated BUN. HEMA: Anemia; neutropenia. HEPA: Elevated liver enzymes. RESP: Cough increased. OTHER: Fever; sweating; weakness; decreased sodium concentration; elevated amylase; allergic reaction; rhinitis; asthenia; infection; dyspnea.

Drug Mode of Action ::  

 Action Inhibits mitochondrial electron transport in metabolic enzymes of microorganisms. This may cause inhibition of nucleic acid and adenosine triphosphate synthesis.

Drug Interactions ::


Food: Food, particularly fats, increases absorption 3-fold. Highly protein-bound drugs: Atovaquone is highly protein bound; interactions may occur because of competition for binding sites. Rifamycins: Decreases steady-state plasma concentrations of atovaquone and increases steady-state plasma concentrations of rifampin.

Drug Assesment ::


  • Obtain patient history, including drug history and any known allergies, particularly to antifungal medications. Note existing GI disorders, because these may limit absorption of orally-administered drug.
  • Monitor patient closely for several hours after administering the first dose, even if there is no history of allergy.
  • Monitor renal and GI function during therapy.
  • Observe for signs of superinfection during therapy (eg, yeast infections, black “hairy” tongue, itching in groin area).
  • Monitor for effectiveness during therapy (eg, decreased temperature, decreased lung congestion).
  • If signs and symptoms of hypersensitivity occur (eg, rash, shortness of breath), withhold medication and notify physician.
  • If no improvement in infection occurs within 5 days, notify physician.
  • If severe GI side effects occur, notify physician.

Drug Storage/Management ::


  • Most effective if administered with food, particularly proteins and fats.
  • Do not freeze.

Drug Notes ::

 Patient/Family Education

  • Inform patient that medication is most effective when taken with food (particularly fatty foods), and to notify physician if unable to eat.
  • Inform patient that slight rash may develop while taking medication.
  • Teach patient to recognize signs of oral fungal infections.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.


One of the 1st in India.High Quality Generic Medicine Portal Android Application for Online Oreder & Information.

For More Join Our Membership and Get Additional 25% off on Meds, also get MLM Benefits to get a permanent earning source.

Join Membership How to Search Medicine
Android App

We would like to keep you updated with special notifications.