Details About Generic Salt ::  Butorpha

Main Medicine Class:: Narcotic agonist-antagonist analgesic   

(byoo-TORE-fan-ahl TAR-trate)

Stadol, Stadol NS

Class: Narcotic agonist-antagonist analgesic

Drugs Class ::

 Action Potent analgesic that stimulates and inhibits opiate receptors in CNS. Antagonist effects decrease (but do not eliminate) abuse potential and may cause withdrawal symptoms in patients with opiate dependence.

Indications for Drugs ::

 Indications Parenteral/nasal Management of pain, including postoperative and migraine. Parenteral Preoperative or preanesthetic medication (to supplement balanced anesthesia); relief of pain during labor.

Drug Dose ::

 Route/Dosage

Pain

ADULTS: IV 0.5 to 2 mg q 3 to 4 hr prn. IM 1 to 4 mg q 3 to 4 hr prn. Single doses not > 4 mg. Nasal 1 mg (1 spray in one nostril). If no relief in 30 to 90 min, may repeat as 1 mg dose. For severe pain initial dose of 2 mg can be used if patient can remain lying down. Do not repeat for 3 to 4 hr. ELDERLY: IV/IM ½ normal dose at twice normal interval. Titrate subsequent doses to response. Nasal Initial dose: 1 mg. Wait 90 to 120 min before giving second 1 mg dose.

Preoperative/Preanesthetic

ADULTS: USUAL DOSE: IM 2 mg 60 to 90 min before surgery.

Labor

ADULTS: IV/IM 1 to 2 mg in early labor at term; repeat after 4 hr.

Kidney or Liver Impairment

ADULTS: IM/IV Increase dosing interval to q 6 to 8 hr initially. Titrate subsequent doses to response.

Contraindication ::

 Contraindications Standard considerations.

Drug Precautions ::

 Precautions

Pregnancy: Category C. Lactation: Excreted in breast milk. Children: Not recommended for children < 18 yr. Cardiovascular disease: Drug increases cardiac workload. Severe hypertension has occurred. Drug dependence: Although potential for physical dependence is low, abuse may occur. Tolerance and psychological and physical dependence may occur with long-term use. Use in patients physically dependent on opiate agonists may precipitate withdrawal symptoms. Elderly: More sensitive to effects; reduce dose. Head injury or increased intracranial pressure: Use with caution; drug can increase cerebrospinal fluid pressure.

Drug Side Effects ::

 Adverse Reactions

CV: Vasodilation; palpitations. CNS: Sedation; floating sensation; dizziness; confusion; headache; lethargy; insomnia. DERM: Sweating; clammy skin. EENT: Nasal use: Tinnitus; ear pain; nasal and sinus congestion; epistaxis; nasal irritation; upper respiratory infections; unpleasant taste. GI: Nausea; vomiting; anorexia; constipation; dry mouth. RESP: Respiratory depression; dyspnea (nasal use).

Drug Mode of Action ::  

 Action Potent analgesic that stimulates and inhibits opiate receptors in CNS. Antagonist effects decrease (but do not eliminate) abuse potential and may cause withdrawal symptoms in patients with opiate dependence.

Drug Interactions ::

 Interactions

Barbiturate anesthetics: Increased CNS and respiratory depression. CNS depressants (eg, tranquilizers, sedatives, alcohol): Additive CNS depression.

Drug Assesment ::

 Assessment/Interventions

• Obtain patient history, including drug history and any known allergies. Note history of drug abuse; neurologic, cardiovascular, renal or liver disease.
• Take vital signs and auscultate heart and lungs before administration. Do not administer if respiratory rate is < 12/min.
• Institute fall precautions and assist with ambulation after administration.
• Monitor BP frequently to check for widening pulse pressure. If hypertension develops, withhold medication and call physician.
• Shallow respirations (< 10/min) may indicate impending respiratory arrest and need for respiratory assistance or stimulation.
• If drug is used during labor, observe fetal heart rate for signs of distress and newborn for signs of respiratory depression.

Drug Storage/Management ::

 Administration/Storage

• When giving by IM route, use deep, slow injection.
• When giving by direct IV infusion, drug may be given undiluted. Administer over 3 to 5 min.
• Store at room temperature, away from light.

Drug Notes ::

 Patient/Family Education

• Demonstrate proper use of nasal spray for patients receiving drug via this route.
• Advise elderly patients to take safety precautions (eg, rise slowly, use handrails, request assistance with ambulation) if dizziness occurs.
• Explain that physical dependency can result from extended use.
• Instruct patient to avoid intake of alcoholic beverages or other CNS depressants.
• Advise patient that drug may cause drowsiness, and to use caution while driving or performing other tasks requiring mental alertness.
• Instruct patient not to take otc medications without consulting physician.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.