Details About Generic Salt ::  Cefmetaz

Main Medicine Class::    

(seff-MET-uh-zole)

Zefazone

Class: Antibiotic/cephalosporin

Drugs Class ::

 Action Inhibits mucopeptide synthesis in bacterial cell wall.

Indications for Drugs ::

 Indications Treatment of infections of urinary tract, lower respiratory tract, skin and skin structure; treatment of intra-abdominal infections due to susceptible microorganisms; peri-operative prophylaxis.

Drug Dose ::

 Route/Dosage

ADULTS: IV 2 g q 6–12 hr.

Perioperative Prophylaxis

ADULTS: IV 1–2 g at specified times prior to surgery.

Abdominal Hysterectomy/Cholecystectomy (High-Risk)

ADULTS: IV 1 g 30–90 min before surgery and repeated 8 hr and 16 hr later.

Cesarean Section

ADULTS: IV 2 g after clamping cord or 1 g after clamping cord and repeated 8 hr and 16 hr later.

Colorectal Surgery/Vaginal Hysterectomy

ADULTS: IV 2 g 30–90 min before surgery or 1–2 g 30–0 min before surgery and repeated 8 hr and 16 hr later.

Contraindication ::

 Contraindications Hypersensitivity to cephalosporins.

Drug Precautions ::

 Precautions

Pregnancy: Category B. Lactation: Excreted in breast milk. Children: Safety and efficacy not established. Pseudomembranous colitis: Should be considered in patients in whom diarrhea develops. Renal impairment: Use drug with caution. Dosage adjustment based on renal function may be required. Superinfection: Drug may cause bacterial or fungal overgrowth of nonsusceptible microorganisms.

Drug Side Effects ::

 Adverse Reactions

CV: Hypotension; shock. CNS: Headache; hot flashes. GI: Nausea; vomiting; diarrhea; abdominal pain or cramps; flatulence; colitis, including pseudomembranous colitis. GU: Renal dysfunction; increased BUN; increased creatinine. HEMA: Eosinophilia; neutropenia; lymphocytosis; leukocytosis; thrombocytopenia; decreased platelet function; anemia; aplastic anemia; hemorrhage. HEPA: Hepatic dysfunction; abnormal liver function test results. RESP: Shortness of breath; pleural effusion. OTHER: Hypersensitivity, including Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis; candidal overgrowth; serum sickness-like reactions (eg, skin rash, polyarthritis, arthralgia, fever); phlebitis, thrombophlebitis and pain at injection site.

Drug Mode of Action ::  

 Action Inhibits mucopeptide synthesis in bacterial cell wall.

Drug Interactions ::

 Interactions

Alcohol: May cause acute alcohol intolerance (disulfiram-like reaction); reaction may occur several days after last dose of cefmetazole. Aminoglycosides: May increase risk of nephrotoxicity. Anticoagulants, oral: May increase anticoagulant effects; may cause bleeding complications. Probenecid: Inhibition of renal excretion of cefmetazole. INCOMPATIBILITIES: Aminoglycosides: Do not add aminoglycosides to cefmetazole solutions because inactivation of both drugs may result; administer at separate sites if concurrent therapy is indicated.

Drug Assesment ::

 Assessment/Interventions

• Obtain patient history, including drug history and any known allergies. Note allergy to cephalosporins or penicillins.
• Obtain specimens for culture and sensitivity before beginning therapy and during treatment.
• Monitor renal function during therapy.
• Monitor IV site during infusion.
• Monitor for signs of infection, especially fever, and for positive response to antibiotic therapy.
• Assess for signs and symptoms of anaphylaxis (shortness of breath, wheezing, laryngeal spasm). Have resuscitation equipment available.
• Assess for signs of superinfection, such as vaginitis or stomatitis.
• Assess for diarrhea with blood or pus, which may be symptom of pseudomembranous colitis. Symptoms may occur after antibiotic treatment.
• Monitor IV site for infiltration, infection, and thrombophlebitis.

Drug Storage/Management ::

 Administration/Storage

• Administer intravenously.
• Reconstitute in ratio of 1 g/10 ml of Sterile Water for Injection, D5W or 0.9% Sodium Chloride for Injection.
• May store drug at room temperature for 24 hr after reconstitution. Reconstituted drug is stable for 7 days if refrigerated and for 6 wk if frozen. Do not use if solution is cloudy or precipitate is present.

Drug Notes ::

 Patient/Family Education

• Instruct patient to check body temperature daily. If fever persists for more than a few days or if high fever (> 102°F) or shaking chills are noted, physician should be notified immediately.
• Advise patient to maintain normal fluid intake while using this medication.
• Advise diabetic patient to use enzyme-based tests (eg, Clinistix, Tes-tape) for monitoring urine glucose because drug may give false results with other tests.
• Instruct patient to report these symptoms to physician: nausea, vomiting, diarrhea, skin rash, hives, sore throat, bruising, bleeding, muscle or joint pain.
• Instruct patient to report signs of superinfection: black “furry” tongue, white patches in mouth, foul-smelling stools, vaginal itching or discharge.
• Warn patient that diarrhea that contains blood or pus may be a sign of serious disorders. Tell patient to seek medical care and not to treat at home.
• Instruct patient to seek emergency care if wheezing or difficulty in breathing occurs.
• Advise patient not to drink alcoholic beverages or to take alcohol-containing medications while receiving cefmetazole and for several days after discontinuing drug.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.