Details About Generic Salt ::  Cyanocob

Main Medicine Class:: Blood modifier, Vitamin   

(sigh-an-oh-koe-BAL-uh-min)

Big Shot B-12

Tablets: 5000 mcg

Crystamine Injection: 1000 mcg/mL

Crysti 1000 Injection: 1000 mcg/mL

Cyanoject Injection: 1000 mcg/mL

Cyomin Injection: 1000 mcg/mL

Nascobal Gel, intranasal: 500 mcg/0.1 mL

Rubesol-1000 Injection: 1000 mcg/mL

Rubramin

Class: Blood modifier, Vitamin

Drugs Class ::

 Action Involved in protein synthesis; essential to growth, cell reproduction, hematopoiesis, and nucleoprotein and myelin synthesis.

Indications for Drugs ::

 Indications Treatment of vitamin B₁₂ deficiency caused by inadequate utilization of vitamin B₁₂; dietary deficiency of vitamin B₁₂ occurring in strict vegetarians; malabsorption syndrome of various causes (eg, pernicious anemia, GI pathology, fish tapeworm infestation, malignancy of pancreas or bowel, gluten enteropathy, small bowel bacterial overgrowth, gastrectomy, accompanying folic acid deficiency); supplementation because of increased requirements (eg, associated with pregnancy, thyrotoxicosis, hemolytic anemia, hemorrhage, malignancy, hepatic and renal disease); vitamin B₁₂ absorption test (eg, Schilling test).

Drug Dose ::

 Route/Dosage

Recommended Dietary Allowance

Adults: PO 2 mcg/day. Children: PO 0.3 to 2 mcg/day.

Vitamin B₁₂ Deficiency

Adults: PO 25 to 1000 mcg/day.

IM or deep SC 30 mcg/day for 5 to 10 days followed by 100 to 200 mcg/mo.

Intranasal 500 mcg once weekly after malabsorption is in remission following injectable therapy.

Addisonian Pernicious Anemia

Adults: IM or deep SC 100 mcg/day for 6 to 7 days. If reticulocyte response occurs, give 100 mcg qod for 7 doses, then give 100 mcg q 3 to 4 days for 2 to 3 wk. After this regimen, give 100 mcg/mo for life.

Shilling Test Flushing Dose

Adults IM 1000 mcg (z-tract method preferred).

Contraindication ::

 Contraindications Hypersensitivity to cobalt, vitamin B₁₂, or any component of these medications; hereditary optic nerve atrophy.

Drug Precautions ::

 Precautions

Pregnancy: Category A (Category C in doses that exceed the RDA). Lactation: Excreted in breast milk. Children: Some products contain benzyl alcohol, which has been associated with fatal “gasping syndrome” in premature infants. Hypersensitivity: Anaphylactic shock and death have been associated with parenteral use. Hypokalemia: Possibly fatal hypokalemia could occur as result of increased erythrocyte potassium requirements in severe megaloblastic anemia intensely treated with vitamin B₁₂.

Drug Side Effects ::

 Adverse Reactions

With parenteral/intranasal administration:

CARDIOVASCULAR: Pulmonary edema; CHF; peripheral vascular thrombosis. DERMATOLOGIC: Itching; transitory exanthema; urticaria. EENT: Severe and rapid optic nerve atrophy. GI: Mild transient diarrhea. OTHER: Hypersensitivity; pain at injection site; sensation of body swelling; hypokalemia; polycythemia vera. Intranasal: Asthenia; headache; infection; glossitis; nausea; paresthesia; rhinitis.

Drug Mode of Action ::  

 Action Involved in protein synthesis; essential to growth, cell reproduction, hematopoiesis, and nucleoprotein and myelin synthesis.

Drug Interactions ::

 Interactions

Chloramphenicol: Decreases hematologic effects of vitamin B₁₂ in patients with pernicious anemia. Colchicine, excessive alcohol intake (more than 2/wk) neomycin, time-released potassium, para-aminosalicylic acid: Decreases GI absorption of vitamin B₁₂.

Drug Assesment ::

 Assessment/Interventions

• Obtain patient history, including drug history and any known allergies. Note any history of Leber disease or sensitivity to cobalt and vitamin B₁₂.
• Obtain baseline reticulocyte counts, hematocrit, vitamin B₁₂, iron and folic acid levels, and then repeat tests between 5th and 7th days of treatment.
• Obtain periodic hematology tests as long as patient is on therapy.
• Monitor serum potassium levels during the first 48 hr of treatment.
• Throughout treatment, monitor and report vision changes to health care provider.
• Report signs of hypersensitivity (eg, urticaria, redness, itching) and hypokalemia (eg, muscle weakness, heart irregularity) to health care provider.

Drug Storage/Management ::

 Administration/Storage

• If patient is sensitive to cobalamins, perform an intradermal skin test prior to administering drug.
• Give IM injection or deep SC injection in large muscle mass.
• Parenteral administration is required in treatment of pernicious anemia.
• Prime intranasal gel dispenser prior to initial use.
• Protect parenteral and intranasal vitamin B₁₂ from light. Do not freeze.

Drug Notes ::

 Patient/Family Education

• Instruct patient with pernicious anemia of need to continue therapy throughout lifetime.
• Advise patient to administer intranasal gel at least 1 hr before or 1 hr after ingestion of hot foods or liquids.
• Advise patient with nasal congestion, allergic rhinitis, or upper respiratory tract infections to defer treatment with intranasal gel until symptoms have subsided.
• Teach patient of need to maintain well-balanced diet. Remind patient of the following good sources of vitamin B₁₂: seafood, egg yolks, organ meats, fortified breakfast cereals, meat, cheeses, milk, other dairy products.
• Advise patient that folic acid is not substitute for vitamin B₁₂ but may be taken concurrently.
• Instruct vegetarians who do not use animal products of need for daily oral vitamin B₁₂.
• Inform patient with pernicious anemia of need to have periodic GI evaluations.
• Instruct patient to report the following symptoms to health care provider: muscle weakness, shortness of breath, heart irregularity, vision disturbances.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.