Details About Generic Salt ::  Diphenhy

Main Medicine Class::    

(die-fen-HIGH-druh-meen HIGH-droe-KLOR-ide)

40 Winks

Tablets

50 mg

Allergy Medication

Liquid

12.5 mg/5 mL

AllerMax

Tablets

50 mg

AllerMax Allergy and Cough Formula

Liquid

6.25 mg/5 mL

Banophen

Capsules

25 mg

Benadryl

Injection

50 mg/mL

Benadryl Allergy

Capsules, soft-gels

25 mg

Tablets

25 mg

Tablets, chewable

12.5 mg

Liquid

12.5 mg/5 mL

Benadryl Allergy Ultratabs

Tablets

25 mg

Benadryl Dye Free

Liquid

12.5 mg/5 mL

Benadryl Dye Free Allergy Liqui Gels

Capsules, soft gels

25 mg

Bydramine Cough

Syrup

12.5 mg/5 mL

Compoz Gel Caps

Capsules

25 mg

Compoz Nighttime Sleep Aid

Tablets

50 mg

Diphen AF

Liquid

6.25 mg/5 mL

Diphen Cough

Syrup

12.5 mg/5 mL

Diphenhist

Solution

12.5 mg/5 mL

Diphenhist Captabs

Tablets

25 mg

Dormin

Tablets

25 mg

Capsules

25 mg

Genahist

Liquid

12.5 mg/5 mL

Hyrexin-50

Injection

50 mg/mL

Maximum Strength Nytol

Tablets

50 mg

Maximum Strength Sleepinal Capsules and Soft Gels

Capsules

50 mg

Maximum Strength Unisom SleepGels

Capsules

50 mg/mL

Midol PM

Tablets

50 mg

Miles Nervine

Tablets

25 mg

Nighttime Sleep Aid

Tablets

50 mg

Nytol

Tablets

25 mg

Scot-Tussin Allergy DM

Liquid

12.5 mg/5 mL

Siladryl

Elixer

12.5 mg/5 mL

Silphen DM

Syrup

10 mg/5 mL

Sleep-Eze 3

Tablets

25 mg

Sleepwell 2-nite

Tablets

25 mg

Snoozefast

Tablets

50 mg

Sominex

Tablets

25 mg

Tablets

50 mg

Sylphen Cough

Syrup

12.5 mg/5 mL

Tusstat

Syrup

12.5 mg/5 mL

Twilite

Tablets

50 mg

Uni-Bent Cough

Syrup

12.5 mg/5 mL

Wehdryl

Allerdryl

Nytol Extra Strength

PMS-Diphenhydramine

Scheinpharm Diphenhydramine

Antihistamine, Ethanolamine

 

Drugs Class ::

 Action Competitively antagonizes histamine at H₁ receptor sites.

Indications for Drugs ::

 Indications Symptomatic relief of perennial and seasonal allergic rhinitis, vasomotor rhinitis and allergic conjunctivitis; temporary relief of runny nose and sneezing caused by common cold; relief of allergic and nonallergic pruritic symptoms; treatment of urticaria and angioedema; amelioration of allergic reactions to blood or plasma; adjunct to epinephrine and other standard measures in anaphylaxis; relief of uncomplicated allergic conditions of immediate type when oral therapy is impossible or contraindicated (parenteral form); treatment and prophylactic treatment of motion sickness; nighttime sleep aid; management of parkinsonism (including drug-induced) in elderly who are intolerant of more potent agents, in mild cases in other age groups and in combination with centrally acting anticholinergics; control of cough from colds or allergy (syrup formulations).

Drug Dose ::

 Route/Dosage

Hypersensitivity Reactions, Type 1/Antiparkinsonism/Motion Sickness Adults: PO 25 to 50 mg q 4 to 6 hr (max, 300 mg/day). IV/IM 10 to 100 mg (rate not exceeding 25 mg/min or deep IM; max, 400 mg/day).

Children (6 to under 12 yr): PO 12.5 to 25 mg q 4 to 6 hr (max, 150 mg). IV/IM 5 mg/kg/day or 150 mg/m² /day (max, 300 mg divided into 4 doses at a rate not exceeding 25 mg/min or deep IM).

Nighttime Sleep Aid Adults: PO 50 mg at bedtime.

Cough Suppressant (Syrup) Adults: PO 25 mg q 4 hr (max, 150 mg/24 hr).

Children (6 to 12 yr): PO 12.5 mg q 4 hr (max, 75 mg/24 hr).

Children (2 to 6 yr): PO 6.25 mg q 4 hr (max, 25 mg/24 hr).

Contraindication ::

 Contraindications Hypersensitivity to antihistamines; narrow-angle glaucoma; stenosing peptic ulcer; symptomatic prostatic hypertrophy; asthmatic attack; bladder neck obstruction; pyloroduodenal obstruction; MAOI therapy; history of sleep apnea; use in newborn or premature infants and in nursing women.

Drug Precautions ::

 Precautions

Pregnancy: Category B. Lactation: Excreted in breast milk. Children: Contraindicated in newborn and premature infants. Overdosage may cause hallucinations, convulsions, and death. Antihistamines may diminish mental alertness. In young children drug may produce paradoxical excitation. Use with caution in children younger than 2 yr. Elderly and debilitated patients: Greater risk of dizziness, excessive sedation, syncope, toxic confusional states, and hypotension in patients older than 60 yr. Dosage reduction may be required. Special risk patients: Use with caution in patients predisposed to urinary retention, prostatic hypertrophy, history of bronchial asthma, increased intraocular pressure, hyperthyroidism, cardiovascular disease, or hypertension. Hepatic impairment: Use with caution in patients with cirrhosis or other liver diseases. Hypersensitivity reactions: May occur. Have epinephrine 1:1000 immediately available. Respiratory disease: Generally not recommended to treat lower respiratory tract symptoms including asthma. Sulfites: Some diphenhydramine products may contain sulfites as preservatives and aspartame as sweetener. Avoid in sulfite-allergic patients and in patients with phenylketonuria, respectively.

PATIENT CARE CONSIDERATIONS

Drug Side Effects ::

 Adverse Reactions

CARDIOVASCULAR: Orthostatic hypotension; palpitations; bradycardia; tachycardia; reflex tachycardia; extrasystoles; faintness. CNS: Drowsiness (often transient); sedation; dizziness; faintness; disturbed coordination.EENT: Nasal stuffiness; dry mouth, nose and throat; sore throat. GI: Epigastric distress; nausea; vomiting; diarrhea; constipation; change in bowel habits. HEMATOLOGIC: Hemolytic anemia; thrombocytopenia; agranulocytosis. METABOLIC: Increased appetite, weight gain. RESPIRATORY: Thickening of bronchial secretions; chest tightness; wheezing; respiratory depression. OTHER: Hypersensitivity reactions; photosensitivity.

Drug Mode of Action ::  

 Action Competitively antagonizes histamine at H₁ receptor sites.

Drug Interactions ::

 Interactions

Alcohol, CNS depressants: May cause additive CNS depression.

MAOIs: May increase anticholinergic effects.

Injectable form is incompatible with dexamethasone sodium phosphate, furosemide, iodipamide meglumine, parenteral barbiturates, and phenytoin.

Drug Assesment ::

 Assessment/Interventions

• Obtain patient history, including drug history and any known allergies. Be alert for conditions that may place patient at greater risk for adverse effects (eg, bronchial asthma, glaucoma, prostatic hypertrophy).
• Be prepared to institute supportive treatment (eg, advanced life support) in event of severe adverse reaction or overdose.
• Observe patient for adverse reactions to medication such as dry mouth, headaches, disorientation, drowsiness, tachycardia, shortness of breath, nausea, skin rash, urinary retention, constipation, or increase in BP.
• If administering medication to children or elderly, be alert to fact that they are more likely to experience side effects and paradoxical reactions such as excitement, irritability, sleeplessness.
• Explain that drowsiness may occur at first but will lessen or disappear during long-term therapy.

OVERDOSAGE: SIGNS & SYMPTOMS   Circulatory collapse; cardiac arrest; respiratory depression or arrest; toxic psychosis; coma; stupor; seizures; ataxia; anxiety; incoherence; hyperactivity; combativeness; anhidrosis; fever; hot, dry, or flushed skin; dry mucous membranes; dysphagia; decreased bowel sounds; dilated and sluggish pupils

Drug Storage/Management ::

 Administration/Storage

• If patient is prone to excessive salivation (eg, postencephalitic patients), administer drug after meals. If mouth dries excessively, administer drug before meals.
• Syrup formulations are used only for control of cough.
• If drug is prescribed for motion sickness, administer first dose 30 min prior to exposure to motion.
• Give IM injection deep in muscle.
• Do not administer drug for at least 2 days before skin allergy testing.
• Store in tightly closed containers at room temperature.
• Store injection formulation in light-resistant container and protect from light.

Drug Notes ::

 Patient/Family Education

• Instruct patient not to discontinue long-term therapy without consulting health care provider.
• Warn patient using topical medication to avoid excessive application to skin eruptions.
• Instruct patient to report these symptoms to health care provider: excessive drowsiness or dry mouth, GI upset, constipation, blurred vision, rash, hives, difficulty breathing, difficulty urinating, confusion, fainting, irregular heart rate.
• Encourage patient to take sips of water frequently, suck on ice chips or sugarless hard candy, or chew sugarless gum if dry mouth occurs.
• Instruct patient to avoid intake of alcoholic beverages or other CNS depressants.
• Advise patient that drug may cause drowsiness and to use caution while driving or performing other tasks requiring mental alertness.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.