Details About Generic Salt ::  Isosorb1

Main Medicine Class:: Antianginal   

(EYE-sos-ORE-bide MAH-no-NYE-trate)

ISMO, Imdur, Monoket, Isotrate ER

Class: Antianginal

Drugs Class ::

 Action Relaxation of smooth muscle of venous and arterial vasculature.

Indications for Drugs ::

 Indications Prevention of angina pectoris.

Drug Dose ::

 Route/Dosage

ADULTS: PO 20 mg bid, given 7 hr apart. Extended release tablets are given as 30 (½ of 60 mg tablet) or 60 mg once daily. After several days dosage may be increased to 120 mg (given as two 60 mg tablets) once daily. Rarely, 240 mg may be required.

Contraindication ::

 Contraindications Hypersensitivity to nitrates; severe anemia; closed-angle glaucoma; orthostatic hypotension; head trauma or cerebral hemorrhage.

Drug Precautions ::

 Precautions

Pregnancy: Category C. Lactation: Undetermined. Special risk patients: Use with caution in patients with acute MI, CHF, glaucoma or angina caused by hypertrophic cardiomyopathy. Acute angina: Not indicated for treatment of acute anginal episodes. Orthostatic hypotension: May occur even with small doses; alcohol accentuates this reaction. Tolerance: Tolerance to vascular and antianginal effects may develop.

Drug Side Effects ::

 Adverse Reactions

CV: Tachycardia; palpitations; hypotension; syncope; arrhythmias. CNS: Headache; apprehension; weakness; vertigo; dizziness; agitation; insomnia. DERM: Cutaneous vasodilation with flushing. EENT: Blurred vision. GI: Nausea; vomiting; diarrhea; dyspepsia. GU: Dysuria; urinary frequency; impotence. HEMA: Methemoglobinemia; hemolytic anemia. OTHER: Arthralgia; perspiration; pallor; cold sweat; edema.

Drug Mode of Action ::  

 Action Relaxation of smooth muscle of venous and arterial vasculature.

Drug Interactions ::

 Interactions

Alcohol: Severe hypotension and cardiovascular collapse may occur. Aspirin: Increased nitrate concentration and actions. Calcium channel blockers: Symptomatic orthostatic hypotension. Dihydroergotamine: Increased systolic BP and decreased antianginal effects may develop.

Drug Assesment ::

 Assessment/Interventions

• Obtain patient history, including drug history and any known allergies.
• Advise patient to notify physician if effectiveness of therapy decreases over time; tolerance may develop.
• Instruct patient to report the following symptoms to physician: Nausea, vomiting, abdominal pain, appetite loss, persistent headache, faintness, apprehension, restlessness, chest pain, flushing, excessive sweating, cold sweat, visual disturbances, fever, involuntary passing of urine and feces.
• Caution patient to avoid sudden position changes to prevent orthostatic hypotension.
• Instruct patient to avoid intake of alcoholic beverages or alcohol-containing products.

Drug Storage/Management ::

 Administration/Storage

• Administer first dose on awakening and second dose 7 hr later.
• Give on empty stomach with full glass of water.
• Tablets should not be crushed or chewed and should be swallowed together.
• Store at cool temperature in tightly closed container.

Drug Notes ::

 Assessment/Interventions

• Obtain patient history, including drug history and any known allergies.
• Advise patient to notify physician if effectiveness of therapy decreases over time; tolerance may develop.
• Instruct patient to report the following symptoms to physician: Nausea, vomiting, abdominal pain, appetite loss, persistent headache, faintness, apprehension, restlessness, chest pain, flushing, excessive sweating, cold sweat, visual disturbances, fever, involuntary passing of urine and feces.
• Caution patient to avoid sudden position changes to prevent orthostatic hypotension.
• Instruct patient to avoid intake of alcoholic beverages or alcohol-containing products.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.