Details About Generic Salt ::  Mephente

Main Medicine Class:: Vasopressor   

(meh-FEN-ter-meen SULL-fate)

Wyamine Sulfate

Class: Vasopressor

Drugs Class ::

 Action Acts directly and indirectly (via release of norepinephrine) on beta and alpha receptors, causing increase in cardiac contraction and, to lesser degree, increase in peripheral vasoconstriction.

Indications for Drugs ::

 Indications Treatment of hypotension secondary to ganglionic blockade and to spinal anesthesia; maintenance of blood pressure until blood or blood substitutes may be administered during hypovolemic shock.

Drug Dose ::

 Route/Dosage

Shock and Hypotension

ADULTS: IM 0.5 mg/kg undiluted. IV 1 mg/ml solution in D5W titrated to clinical response.

Hypotension Following Spinal Anesthesia

ADULTS: IV 30–45 mg; repeat doses of 30 mg prn; or give as 1 mg/ml infusion in D5W titrated to clinical response.

Prevention of Hypotension Following Spinal Anesthesia

ADULTS: IM 30–45 mg 10–20 min prior to anesthesia, operation or termination of operative procedure.

Hypotension Secondary to Spinal Anesthesia During Cesarean Section

ADULTS: IV 15 mg; repeat prn.

Hemorrhagic Shock

ADULTS: IV Continuous infusion of 1 mg/ml solution in D5W until whole blood replacement can be accomplished.

Contraindication ::

 Contraindications Hypotension induced by chlorpromazine; use of MAO inhibitors.

Drug Precautions ::

 Precautions

Pregnancy: Category C. Lactation: Undetermined. Cardiovascular effects: May be profound. Use with caution in chronically ill patients and patients with known cardiovascular disease or hyperthyroidism. Hypovolemia: Avoid in patients with uncorrected hypovolemia. Persistent hypotension may indicate hypovolemia.

Drug Side Effects ::

 Adverse Reactions

CV: Cardiac arrhythmias; excessive hypertension, especially in patients with heart disease. CNS: Anxiety; seizures.

Drug Mode of Action ::  

 Action Acts directly and indirectly (via release of norepinephrine) on beta and alpha receptors, causing increase in cardiac contraction and, to lesser degree, increase in peripheral vasoconstriction.

Drug Interactions ::

 Interactions

Guanethidine: Antihypertensive effects of guanethidine may be negated. Halogenated hydrocarbon anesthetics: May sensitize myocardium to arrhythmogenic effects of catecholamines. MAO inhibitors, furazolidone, rauwolfia alkaloids, methyldopa: May significantly increase pressor response, possibly resulting in hypertensive crisis and intracranial hemorrhage. Oxytoxic drugs: Synergistic or additive vasoconstrictive effects may occur, resulting in hypertension and possible gangrene in the extremities. Tricyclic antidepressants: May decrease pressor response.

Drug Assesment ::

 Assessment/Interventions

• Obtain patient history, including drug history and any known allergies.
• Use electronic infusion device for IV administration.
• Monitor I&O. If urinary output is < 30 ml/hr, notify physician.
• Monitor BP during IV administration and every 5 min after IM administration.

Drug Storage/Management ::

 Administration/Storage

• If solution is discolored, do not use; discard.
• IV solution can be prepared by adding 10 or 20 ml of 30 mg/ml mephentermine to 250 ml or 500 ml of D5W, respectively.
• Store reconstituted solution no longer than 24 hr.

Drug Notes ::

 Patient/Family Education

• Instruct patient and family to notify physician if any otc cold or allergy preparation has been used within 3 days of surgery.
• Inform physician of use of MAO inhibitors or tricyclic antidepressants within 1 mo of surgery.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.