Details About Generic Salt ::  Nafareli

Main Medicine Class:: Gonadotropin-releasing hormone   

Class: Gonadotropin-releasing hormone


Drugs Class ::

 Action Initially causes synthesis and release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). With continued use (> 4 wk) suppresses secretion of LH and FSH.

Indications for Drugs ::

 Indications Treatment of endometriosis, central precocious puberty in children of both sexes.

Drug Dose ::



ADULTS: Intranasal 400 mcg/day (200 mcg [1 spray] in 1 nostril in morning and 200 mcg [1 spray] in other nostril in evening. For long-term suppression, 800 mcg/day (1 spray in each nostril bid) may be necessary.

Central Precocious Puberty

CHILDREN: Intranasal 1600 mcg/day (400 mcg [2 sprays] in each nostril in morning and 400 mcg [2 sprays] in each nostril in evening). In some patients 1800 mcg/day (3 sprays in alternating nostrils tid) may be necessary.

Contraindication ::

 Contraindications Hypersensitivity to gonadotropin-releasing hormone (GnRH); or GnRH-agonist analogs; undiagnosed abnormal vaginal bleeding; pregnancy; lactation.

Drug Precautions ::


Pregnancy: Category X. Lactation: Do not use in lactating women. Bone density loss: May be small loss in bone density during therapy, some of which may not be reversible. Risk is greater in patients who smoke or have osteoporosis and in alcoholics. Intercurrent rhinitis: If patient must use topical nasal decongestant during nafarelin therapy, should be used ³ 2 hr after nafarelin dosing to decrease possibility of reduced absorption. Menstruation: Should stop with effective doses. Noncompliance: Irregular or incomplete doses may result in stimulation of pituitary-gonadal axis. Ovarian cysts: Have occurred in first 2 mo of therapy.


Drug Side Effects ::

 Adverse Reactions

CNS: Headaches; insomnia; depression. DERM: Acne; seborrhea. EENT: Nasal irritation. GU: Vaginal dryness. OTHER: Hot flushes; decreased libido; emotional lability; myalgia; reduced breast size; edema; weight gain; hirsutism; decreased bone density.

Drug Mode of Action ::  

 Action Initially causes synthesis and release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). With continued use (> 4 wk) suppresses secretion of LH and FSH.

Drug Interactions ::


None well documented.

Drug Assesment ::


  • Obtain patient history, including drug history and any known allergies.
  • Obtain baseline assessments of last menstrual period, pregnancy status in patients with endometriosis, height and weight in patients with central precocious puberty.
  • Monitor menstrual cycles.
  • Monitor for drug-related hypoestrogenism. Note patient complaints of hot flushes, libido decrease, vaginal dryness, headaches, emotional lability.
  • Monitor for signs of androgenism, including acne, myalgia, breast size reduction, edema, weight gain.

Drug Storage/Management ::


  • When treating endometriosis, begin treatment between days 2 and 4 of menstrual cycle.
  • Administer intranasally with metered-spray pump. Patient’s head should be tilted back slightly.
  • If administering > 1 spray per nostril, wait 30 sec between sprays.
  • Store container upright at room temperature.
  • Protect from light.

Drug Notes ::

 Patient/Family Education

  • Caution patient that this medication must not be taken during pregnancy or when pregnancy is possible. Advise patient to use nonhormonal form of birth control while taking this drug.
  • Advise patient regarding proper administration techniques and storage information.
  • Tell patient to begin treatment between days 2 and 4 of menstrual cycle if being treated for endometriosis.
  • Instruct patient not to blow nose and to avoid sneezing immediately after administration.
  • Tell patient using topical nasal decongestant to use 2 hr after nafarelin has been administered.
  • Advise patient that each bottle contains » 60 sprays and plan refills accordingly.
  • Explain side effects of medication and instruct patient to report the following symptoms to physician: Bleeding/menses continues, breakthrough bleeding or adverse/side effects.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.


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